Endoscopically implantable devices into submucosa as the solution for low-gravity induced gastrointestinal problems

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Endoscopically implantable devices into submucosa as the solution for low-gravity induced gastrointestinal problems

Popis výsledku v původním jazyce

The future manned space missions will be challenging not only from technical point of view but medical as well. Although the process of selecting suitable candidates is rigorous, medical complications can still occur during longterm space flight. Gastrointestinal problems are a quite significant group of all medical events among astronauts. One of the main gastrointestinal problems is the gastroesophageal reflux disease (GERD). The gravity normally keeps the acid reflux from developing. However, in low gravity or microgravity, the acid can press against lower esophageal sphincter easier which may lead to GERD. We developed a method to address these challenges with a battery-less endoscopically implantable device. A miniature implantable capsule (14 mm x 14 mm x 6 mm) was designed to assess the technology. It is powered wirelessly using inductive coupling with the transmitter coil and features two-lead bipolar electrical stimulation. The experiments were performed in an animal model and living animals. The device was endoscopically implanted into submucosal space near lower esophageal sphincter. The device stimulates the muscularis propria inside esophagus to prevent GERD. Minimal invasiveness and virtually no bleeding during surgery when compared to today&apos;s solutions for neurostimulation make the presented solution a novel approach which could be carried out in space or before space flight without the need for full anaesthesia. Future work will be focused on implementing different types of sensors and actuators to treat different gastrointestinal diseases which could occur during long-term spaceflight.

Název v anglickém jazyce

Endoscopically implantable devices into submucosa as the solution for low-gravity induced gastrointestinal problems

Popis výsledku anglicky

The future manned space missions will be challenging not only from technical point of view but medical as well. Although the process of selecting suitable candidates is rigorous, medical complications can still occur during longterm space flight. Gastrointestinal problems are a quite significant group of all medical events among astronauts. One of the main gastrointestinal problems is the gastroesophageal reflux disease (GERD). The gravity normally keeps the acid reflux from developing. However, in low gravity or microgravity, the acid can press against lower esophageal sphincter easier which may lead to GERD. We developed a method to address these challenges with a battery-less endoscopically implantable device. A miniature implantable capsule (14 mm x 14 mm x 6 mm) was designed to assess the technology. It is powered wirelessly using inductive coupling with the transmitter coil and features two-lead bipolar electrical stimulation. The experiments were performed in an animal model and living animals. The device was endoscopically implanted into submucosal space near lower esophageal sphincter. The device stimulates the muscularis propria inside esophagus to prevent GERD. Minimal invasiveness and virtually no bleeding during surgery when compared to today&apos;s solutions for neurostimulation make the presented solution a novel approach which could be carried out in space or before space flight without the need for full anaesthesia. Future work will be focused on implementing different types of sensors and actuators to treat different gastrointestinal diseases which could occur during long-term spaceflight.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the International Astronautical Congress; Vol. 3

ISBN

978-1-5108-5537-3

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

4

Strana od-do

1961-1964

Název nakladatele

International Astronautical Federation

Místo vydání

Paris

Místo konání akce

Adelaide, Australia

Datum konání akce

25. 9. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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