Long-term early life adverse experience impairs responsiveness to exteroceptive stimuli in adult rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916316" target="_blank" >RIV/00216208:11120/18:43916316 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/18:00492119

Výsledek na webu

<a href="https://doi.org/10.1016/j.beproc.2018.02.005" target="_blank" >https://doi.org/10.1016/j.beproc.2018.02.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.beproc.2018.02.005" target="_blank" >10.1016/j.beproc.2018.02.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term early life adverse experience impairs responsiveness to exteroceptive stimuli in adult rats

Popis výsledku v původním jazyce

It has been shown that early life traumatic events strongly alter the physiology and behavior in adult rats. In the present study, the effect of postnatal stressor on the spontaneous behavior of adult male rats was evaluated. A method of positive habituation based on a detailed analysis of behavioral patterns and attention of animals to a stimulus object was used. Twenty-four dams and twenty-four of their male progeny were used. Pups were divided into three groups (n = 8): controls (C); maternal social stressor (S); maternal social and physical stressors (SW). Animals (postnatal day 70-80) were individually placed in the open field arena in two habituation sessions with a 24-h delay between them (Test day 1 and Test day 2). Before the start of third session (Test day 3) a solid object was fixed in the center of the arena. Each test lasted 10 min. Our results showed the habituation effect in both stressed-groups. Although there were no significant differences in the number of investigations of the novel object among all tested groups, stress-exposed rats spent less time investigating the object. In conclusion, our findings indicate that long-term neonatal stress may impair an animal&apos;s ability to sustain attention to stimuli.

Název v anglickém jazyce

Long-term early life adverse experience impairs responsiveness to exteroceptive stimuli in adult rats

Popis výsledku anglicky

It has been shown that early life traumatic events strongly alter the physiology and behavior in adult rats. In the present study, the effect of postnatal stressor on the spontaneous behavior of adult male rats was evaluated. A method of positive habituation based on a detailed analysis of behavioral patterns and attention of animals to a stimulus object was used. Twenty-four dams and twenty-four of their male progeny were used. Pups were divided into three groups (n = 8): controls (C); maternal social stressor (S); maternal social and physical stressors (SW). Animals (postnatal day 70-80) were individually placed in the open field arena in two habituation sessions with a 24-h delay between them (Test day 1 and Test day 2). Before the start of third session (Test day 3) a solid object was fixed in the center of the arena. Each test lasted 10 min. Our results showed the habituation effect in both stressed-groups. Although there were no significant differences in the number of investigations of the novel object among all tested groups, stress-exposed rats spent less time investigating the object. In conclusion, our findings indicate that long-term neonatal stress may impair an animal&apos;s ability to sustain attention to stimuli.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA18-03806S" target="_blank" >GA18-03806S: Vliv různých prostředí na kognitivní funkce u dospívajících potkaních samců prenatálně exponovaných metamfetaminu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Behavioural Processes

ISSN

0376-6357

e-ISSN

—

Svazek periodika

149

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

59-64

Kód UT WoS článku

000427337400008

EID výsledku v databázi Scopus

2-s2.0-85042173267