Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916349" target="_blank" >RIV/00216208:11120/18:43916349 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.jns.2018.02.026" target="_blank" >https://doi.org/10.1016/j.jns.2018.02.026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2018.02.026" target="_blank" >10.1016/j.jns.2018.02.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study

Popis výsledku v původním jazyce

Background: The relationship between fatigue impact and walking capacity and perceived ability in patients with multiple sclerosis (MS) is inconclusive in the existing literature. A better understanding might guide new treatment avenues for fatigue and/or walking capacity in patients with MS. Objective: To investigate the relationship between the subjective impact of fatigue and objective walking capacity as well as subjective walking ability in MS patients. Methods: A cross-sectional multicenter study design was applied. Ambulatory MS patients (n = 189, age: 47.6 +- 10.5 years; gender: 115/74 women/men; Expanded Disability Status Scale (EDSS): 4.1 +- 1.8 [range: 0-6.5]) were tested at 11 sites. Objective tests of walking capacity included short walking tests (Timed 25-Foot Walk (T25FW), 10-Metre Walk Test (10mWT) at usual and fastest speed and the timed up and go (TUG)), and long walking tests (2- and 6-Minute Walk Tests (MWT). Subjective walking ability was tested applying the Multiple Sclerosis Walking Scale-12 (MSWS-12). Fatigue impact was measured by the self-reported modified fatigue impact scale (MFIS) consisting of a total score (MFIStotal) and three subscales (MFISphysical, MFIScognitive and MFISpsychosocial). Uni- and multivariate regression analysis were performed to evaluate the relation between walking and fatigue impact. Results: MFIStotal was negatively related with long (6MWT, r = MINUS SIGN 0.14, p = 0.05) and short composite (TUG, r = MINUS SIGN 0.22, p = 0.003) walking measures. MFISphysical showed a significant albeit weak relationship to walking speed in all walking capacity tests (r = MINUS SIGN 0.22 to MINUS SIGN 0.33, p &lt;.0001), which persisted in the multivariate linear regression analysis. Subjective walking ability (MSWS-12) was related to MFIStotal (r = 0.49, p &lt; 0.0001), as well as to all other subscales of MFIS (r = 0.24-0.63, p &lt; 0.001), showing stronger relationships than objective measures of walking. Conclusions: The physical impact of fatigue is weakly related to objective walking capacity, while general, physical, cognitive and psychosocial fatigue impact are weakly to moderately related to subjective walking ability, when analysed in a large heterogeneous sample of MS patients.

Název v anglickém jazyce

Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study

Popis výsledku anglicky

Background: The relationship between fatigue impact and walking capacity and perceived ability in patients with multiple sclerosis (MS) is inconclusive in the existing literature. A better understanding might guide new treatment avenues for fatigue and/or walking capacity in patients with MS. Objective: To investigate the relationship between the subjective impact of fatigue and objective walking capacity as well as subjective walking ability in MS patients. Methods: A cross-sectional multicenter study design was applied. Ambulatory MS patients (n = 189, age: 47.6 +- 10.5 years; gender: 115/74 women/men; Expanded Disability Status Scale (EDSS): 4.1 +- 1.8 [range: 0-6.5]) were tested at 11 sites. Objective tests of walking capacity included short walking tests (Timed 25-Foot Walk (T25FW), 10-Metre Walk Test (10mWT) at usual and fastest speed and the timed up and go (TUG)), and long walking tests (2- and 6-Minute Walk Tests (MWT). Subjective walking ability was tested applying the Multiple Sclerosis Walking Scale-12 (MSWS-12). Fatigue impact was measured by the self-reported modified fatigue impact scale (MFIS) consisting of a total score (MFIStotal) and three subscales (MFISphysical, MFIScognitive and MFISpsychosocial). Uni- and multivariate regression analysis were performed to evaluate the relation between walking and fatigue impact. Results: MFIStotal was negatively related with long (6MWT, r = MINUS SIGN 0.14, p = 0.05) and short composite (TUG, r = MINUS SIGN 0.22, p = 0.003) walking measures. MFISphysical showed a significant albeit weak relationship to walking speed in all walking capacity tests (r = MINUS SIGN 0.22 to MINUS SIGN 0.33, p &lt;.0001), which persisted in the multivariate linear regression analysis. Subjective walking ability (MSWS-12) was related to MFIStotal (r = 0.49, p &lt; 0.0001), as well as to all other subscales of MFIS (r = 0.24-0.63, p &lt; 0.001), showing stronger relationships than objective measures of walking. Conclusions: The physical impact of fatigue is weakly related to objective walking capacity, while general, physical, cognitive and psychosocial fatigue impact are weakly to moderately related to subjective walking ability, when analysed in a large heterogeneous sample of MS patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

—

Svazek periodika

387

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

179-186

Kód UT WoS článku

000430775700034

EID výsledku v databázi Scopus

2-s2.0-85042425183