Menthol-based hydrophobic deep eutectic solvents: Towards greener and efficient extraction of phytocannabinoids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916760" target="_blank" >RIV/00216208:11120/18:43916760 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/18:10376799 RIV/00216208:11110/18:10376799 RIV/00023752:_____/18:43919391 RIV/00064165:_____/18:10376799

Výsledek na webu

<a href="https://doi.org/10.1016/j.jclepro.2018.05.080" target="_blank" >https://doi.org/10.1016/j.jclepro.2018.05.080</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jclepro.2018.05.080" target="_blank" >10.1016/j.jclepro.2018.05.080</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Menthol-based hydrophobic deep eutectic solvents: Towards greener and efficient extraction of phytocannabinoids

Popis výsledku v původním jazyce

As the demand for medical cannabis preparations increases, so does the use of the common organic solvents that are used in the extraction and quantification of phytocannabinoids. Since common organic solvents are typically hazardous to the environment and to human health, it is vital to identify safer, greener, and more efficient alternatives. The aim of the present research was to develop a series of hydrophobic deep eutectic solvents (DESs) based on terpenes and natural organic acids and to establish whether these might be potential substitutes for the extraction of phytocannabinoids (tetrahydrocannabinol, cannabidiol, and their carboxylated homologues) from raw cannabis plant material. Data were obtained using capillary electrophoresis with diode array detection (DAD). Initial screening showed that the DES composed of a menthol: acetic acid (1:1 M ratio) mixture showed the greatest extraction efficiency (of all the DESs that were tested), with yields ranging from 118.6% to 132.6% (compared to a methanol: chloroform mixture). In conclusion, menthol: acetic acid DES extraction is efficient, as well as non-toxic and biodegradable. As such it has applications within the pharmaceutical industry and represents a greener alternative organic solvent for the extraction of phytocannabinoids.

Název v anglickém jazyce

Menthol-based hydrophobic deep eutectic solvents: Towards greener and efficient extraction of phytocannabinoids

Popis výsledku anglicky

As the demand for medical cannabis preparations increases, so does the use of the common organic solvents that are used in the extraction and quantification of phytocannabinoids. Since common organic solvents are typically hazardous to the environment and to human health, it is vital to identify safer, greener, and more efficient alternatives. The aim of the present research was to develop a series of hydrophobic deep eutectic solvents (DESs) based on terpenes and natural organic acids and to establish whether these might be potential substitutes for the extraction of phytocannabinoids (tetrahydrocannabinol, cannabidiol, and their carboxylated homologues) from raw cannabis plant material. Data were obtained using capillary electrophoresis with diode array detection (DAD). Initial screening showed that the DES composed of a menthol: acetic acid (1:1 M ratio) mixture showed the greatest extraction efficiency (of all the DESs that were tested), with yields ranging from 118.6% to 132.6% (compared to a methanol: chloroform mixture). In conclusion, menthol: acetic acid DES extraction is efficient, as well as non-toxic and biodegradable. As such it has applications within the pharmaceutical industry and represents a greener alternative organic solvent for the extraction of phytocannabinoids.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cleaner Production

ISSN

0959-6526

e-ISSN

—

Svazek periodika

193

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

391-396

Kód UT WoS článku

000437997200032

EID výsledku v databázi Scopus

2-s2.0-85048201921