Providing direction improves function: Comparison of a radial pore-orientated acellular collagen scaffold to clinical alternatives in a surgically induced rabbit diaphragmatic tissue defect model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916924" target="_blank" >RIV/00216208:11120/18:43916924 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023698:_____/18:N0000007

Výsledek na webu

<a href="https://doi.org/10.1002/term.2734" target="_blank" >https://doi.org/10.1002/term.2734</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/term.2734" target="_blank" >10.1002/term.2734</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Providing direction improves function: Comparison of a radial pore-orientated acellular collagen scaffold to clinical alternatives in a surgically induced rabbit diaphragmatic tissue defect model

Popis výsledku v původním jazyce

Gore-Tex(R) is a widely used durable patch for repair of congenital diaphragmatic defects yet may result in complications. We compared Gore-Tex to a composite of a radial pore orientated collagen scaffold (RP-Composite) and clinically used porcine small intestinal submucosa (SIS; Surgisis(R)) in a rabbit model for diaphragmatic hernia. The growing rabbit mimics the rapid rib cage growth and re-herniation rates seen in children. We created and immediately repaired left hemi-diaphragmatic defects in 6-week-old rabbits with Gore-Tex, SIS and a RP-Composite scaffold. An additional group of rabbits had a sham operation. At 90 days, survivors more than doubled in weight. We observed few re-herniations or eventrations in Gore-Tex (17%) and RP-Composite (22%) implanted animals. However, SIS failed in all rabbits. Maximum transdiaphragmatic pressure was lower in Gore-Tex (71%) than RP-Composite implanted animals (112%) or sham (134%). Gore-Tex repairs were less compliant than RP-Composite, which behaved as sham diaphragm (p&lt;0.01). RP-Composite induced less foreign body giant cell reaction than Gore-Tex (p&lt;0.05) with more collagen deposition (p&lt;0.001), although there was a tendency for the scaffold to calcify. Unlike Gore-Tex, the compliance of diaphragms reconstructed with RP-Composite scaffolds were comparable to native diaphragm, whereas re-herniation rates and transdiaphragmatic pressure measurements were similar.

Název v anglickém jazyce

Providing direction improves function: Comparison of a radial pore-orientated acellular collagen scaffold to clinical alternatives in a surgically induced rabbit diaphragmatic tissue defect model

Popis výsledku anglicky

Gore-Tex(R) is a widely used durable patch for repair of congenital diaphragmatic defects yet may result in complications. We compared Gore-Tex to a composite of a radial pore orientated collagen scaffold (RP-Composite) and clinically used porcine small intestinal submucosa (SIS; Surgisis(R)) in a rabbit model for diaphragmatic hernia. The growing rabbit mimics the rapid rib cage growth and re-herniation rates seen in children. We created and immediately repaired left hemi-diaphragmatic defects in 6-week-old rabbits with Gore-Tex, SIS and a RP-Composite scaffold. An additional group of rabbits had a sham operation. At 90 days, survivors more than doubled in weight. We observed few re-herniations or eventrations in Gore-Tex (17%) and RP-Composite (22%) implanted animals. However, SIS failed in all rabbits. Maximum transdiaphragmatic pressure was lower in Gore-Tex (71%) than RP-Composite implanted animals (112%) or sham (134%). Gore-Tex repairs were less compliant than RP-Composite, which behaved as sham diaphragm (p&lt;0.01). RP-Composite induced less foreign body giant cell reaction than Gore-Tex (p&lt;0.05) with more collagen deposition (p&lt;0.001), although there was a tendency for the scaffold to calcify. Unlike Gore-Tex, the compliance of diaphragms reconstructed with RP-Composite scaffolds were comparable to native diaphragm, whereas re-herniation rates and transdiaphragmatic pressure measurements were similar.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Tissue Engineering and Regenerative Medicine

ISSN

1932-6254

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

2138-2150

Kód UT WoS článku

000450014700002

EID výsledku v databázi Scopus

2-s2.0-85053425877