Comment on Mulukutla et al. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes. Diabetes Care 2018;41:2637-2640

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F19%3A43918116" target="_blank" >RIV/00216208:11120/19:43918116 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.2337/dc19-0022" target="_blank" >https://doi.org/10.2337/dc19-0022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2337/dc19-0022" target="_blank" >10.2337/dc19-0022</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comment on Mulukutla et al. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes. Diabetes Care 2018;41:2637-2640

Popis výsledku v původním jazyce

I read with great interest the article by Mulukutla et al. (1) demonstrating that antibodies against the luminal (extracellular) domain of phosphatase IA-2, termed IA-2EC (amino acids 26-577), are expressed by patients with ketosis-prone diabetes. Among patients that were negative for other αIA-2 autoantibodies, the αIA-2EC antibodies were reported in 2% of patients with ketosis-prone diabetes without the presence of autoantibodies (1), 6% (2) or 7% (3) of patients with type 1 diabetes, and 5% of patients diagnosed with type 2 diabetes (3). Despite the fact that the mRNA signal of IA-2 is ubiquitous and protein expression is high in various neuroendocrine cells, the data on αIA-2EC autoantibodies from other neuroendocrine disorders are lacking.

Název v anglickém jazyce

Comment on Mulukutla et al. Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes. Diabetes Care 2018;41:2637-2640

Popis výsledku anglicky

I read with great interest the article by Mulukutla et al. (1) demonstrating that antibodies against the luminal (extracellular) domain of phosphatase IA-2, termed IA-2EC (amino acids 26-577), are expressed by patients with ketosis-prone diabetes. Among patients that were negative for other αIA-2 autoantibodies, the αIA-2EC antibodies were reported in 2% of patients with ketosis-prone diabetes without the presence of autoantibodies (1), 6% (2) or 7% (3) of patients with type 1 diabetes, and 5% of patients diagnosed with type 2 diabetes (3). Despite the fact that the mRNA signal of IA-2 is ubiquitous and protein expression is high in various neuroendocrine cells, the data on αIA-2EC autoantibodies from other neuroendocrine disorders are lacking.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diabetes Care

ISSN

0149-5992

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

"e81"

Kód UT WoS článku

000465238900007

EID výsledku v databázi Scopus

2-s2.0-85065114320