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Gastric cancer during pregnancy: a report on 13 cases and review of the literature with focus on chemotherapy during pregnancy

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43918759" target="_blank" >RIV/00216208:11120/20:43918759 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00064173:_____/19:N0000157

  • Výsledek na webu

    <a href="https://doi.org/10.1111/aogs.13731" target="_blank" >https://doi.org/10.1111/aogs.13731</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/aogs.13731" target="_blank" >10.1111/aogs.13731</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Gastric cancer during pregnancy: a report on 13 cases and review of the literature with focus on chemotherapy during pregnancy

  • Popis výsledku v původním jazyce

    INTRODUCTION: Gastric cancer during pregnancy is extremely rare and data on optimal treatment and possible chemotherapeutic regimens are scarce. The aim of this study is to describe the obstetric and maternal outcome of patients suffering from gastric cancer during pregnancy and review the literature on antenatal chemotherapy for gastric cancer. MATERIAL AND METHODS: Treatment and outcome of patients registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database with gastric cancer diagnosed during pregnancy were analyzed. RESULTS: In total, 13 patients with gastric cancer during pregnancy were registered between 2002 and 2018. Median gestational age at diagnosis was 22 weeks (range 6 - 30 weeks). Twelve patients were diagnosed with advanced disease and deceased within 2 years after pregnancy, the majority even within 6 months. In total, 8 out of 10 live births ended in a preterm delivery because of pre-eclampsia, maternal deterioration or therapy planning. Two out of six patients that initiated chemotherapy during pregnancy delivered at term. Two neonates prenatally exposed to chemotherapy were growth restricted and one of them developed a systemic infection with brain abscess after preterm delivery for pre-eclampsia two weeks after chemotherapy. No malformations were reported. CONCLUSIONS: The prognosis of gastric cancer during pregnancy is poor, mainly due to advanced disease at diagnosis, emphasizing the need for early diagnosis. Antenatal chemotherapy can be considered in order to reach fetal maturity, taking possible complications as growth restriction, preterm delivery and hematopoietic suppression at birth into account.

  • Název v anglickém jazyce

    Gastric cancer during pregnancy: a report on 13 cases and review of the literature with focus on chemotherapy during pregnancy

  • Popis výsledku anglicky

    INTRODUCTION: Gastric cancer during pregnancy is extremely rare and data on optimal treatment and possible chemotherapeutic regimens are scarce. The aim of this study is to describe the obstetric and maternal outcome of patients suffering from gastric cancer during pregnancy and review the literature on antenatal chemotherapy for gastric cancer. MATERIAL AND METHODS: Treatment and outcome of patients registered in the International Network on Cancer, Infertility and Pregnancy (INCIP) database with gastric cancer diagnosed during pregnancy were analyzed. RESULTS: In total, 13 patients with gastric cancer during pregnancy were registered between 2002 and 2018. Median gestational age at diagnosis was 22 weeks (range 6 - 30 weeks). Twelve patients were diagnosed with advanced disease and deceased within 2 years after pregnancy, the majority even within 6 months. In total, 8 out of 10 live births ended in a preterm delivery because of pre-eclampsia, maternal deterioration or therapy planning. Two out of six patients that initiated chemotherapy during pregnancy delivered at term. Two neonates prenatally exposed to chemotherapy were growth restricted and one of them developed a systemic infection with brain abscess after preterm delivery for pre-eclampsia two weeks after chemotherapy. No malformations were reported. CONCLUSIONS: The prognosis of gastric cancer during pregnancy is poor, mainly due to advanced disease at diagnosis, emphasizing the need for early diagnosis. Antenatal chemotherapy can be considered in order to reach fetal maturity, taking possible complications as growth restriction, preterm delivery and hematopoietic suppression at birth into account.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30214 - Obstetrics and gynaecology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Acta Obstetricia et Gynecologica Scandinavica

  • ISSN

    0001-6349

  • e-ISSN

  • Svazek periodika

    99

  • Číslo periodika v rámci svazku

    1

  • Stát vydavatele periodika

    DK - Dánské království

  • Počet stran výsledku

    10

  • Strana od-do

    79-88

  • Kód UT WoS článku

    000491186800001

  • EID výsledku v databázi Scopus

    2-s2.0-85074288798