Five years of improving diabetes control in Czech children after the establishment of the population-based childhood diabetes register čENDA
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43918900" target="_blank" >RIV/00216208:11120/20:43918900 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/65269705:_____/20:00073049 RIV/00843989:_____/20:E0108269
Výsledek na webu
<a href="https://doi.org/10.1111/pedi.12929" target="_blank" >https://doi.org/10.1111/pedi.12929</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/pedi.12929" target="_blank" >10.1111/pedi.12929</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Five years of improving diabetes control in Czech children after the establishment of the population-based childhood diabetes register čENDA
Popis výsledku v původním jazyce
OBJECTIVES: The Czech National Childhood Diabetes Register (čENDA) is a web-based nationwide database that collects treatment and outcome data in children and adolescents with diabetes. Here we present data from the first five years of čENDA (2013-2017). METHODS: Data include characteristics of disease onset and annual summaries of key clinical care parameters from every patient treated by participating pediatric diabetes outpatient clinics. RESULTS: The database contains data of 4361 children (aged 0 to 19 years) from 52 centers (85 % of all Czech pediatric patients). Of these, 94 % had type 1 diabetes (T1D), 4.5 % had genetically proven monogenic or secondary, and 1.5 % had type 2 diabetes. In children with T1D, median HbA1c decreased throughout the observed period from 66.3 to 61.0 mmol/mol (p < 0.0001, 95% CI for change -5.6 to -4 mmol/mol). Consequently, the proportion of children reaching the target therapeutic goal of 58.5 mmol/mol increased from 28 % in 2013 to 40 % in 2017. The proportion of children treated with insulin pumps (CSII) remained stable over the observed period (25 %). In a subanalysis of 1602 patients (long-standing T1D diagnosed before 2011), the main predictors associated with lower HbA1c were treatment with CSII, male sex and care provided at a large diabetes center (>100 patients). CONCLUSIONS: A significant continuous decrease in HbA1c was observed in Czech children over the past five years. As this improvement was not accompanied by appreciable changes in the mode of therapy, we assume that the establishment of our nationwide register has itself constituted a stimulus towards improvement in the care process.
Název v anglickém jazyce
Five years of improving diabetes control in Czech children after the establishment of the population-based childhood diabetes register čENDA
Popis výsledku anglicky
OBJECTIVES: The Czech National Childhood Diabetes Register (čENDA) is a web-based nationwide database that collects treatment and outcome data in children and adolescents with diabetes. Here we present data from the first five years of čENDA (2013-2017). METHODS: Data include characteristics of disease onset and annual summaries of key clinical care parameters from every patient treated by participating pediatric diabetes outpatient clinics. RESULTS: The database contains data of 4361 children (aged 0 to 19 years) from 52 centers (85 % of all Czech pediatric patients). Of these, 94 % had type 1 diabetes (T1D), 4.5 % had genetically proven monogenic or secondary, and 1.5 % had type 2 diabetes. In children with T1D, median HbA1c decreased throughout the observed period from 66.3 to 61.0 mmol/mol (p < 0.0001, 95% CI for change -5.6 to -4 mmol/mol). Consequently, the proportion of children reaching the target therapeutic goal of 58.5 mmol/mol increased from 28 % in 2013 to 40 % in 2017. The proportion of children treated with insulin pumps (CSII) remained stable over the observed period (25 %). In a subanalysis of 1602 patients (long-standing T1D diagnosed before 2011), the main predictors associated with lower HbA1c were treatment with CSII, male sex and care provided at a large diabetes center (>100 patients). CONCLUSIONS: A significant continuous decrease in HbA1c was observed in Czech children over the past five years. As this improvement was not accompanied by appreciable changes in the mode of therapy, we assume that the establishment of our nationwide register has itself constituted a stimulus towards improvement in the care process.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30209 - Paediatrics
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Pediatric Diabetes
ISSN
1399-543X
e-ISSN
—
Svazek periodika
21
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
11
Strana od-do
77-87
Kód UT WoS článku
000490350900001
EID výsledku v databázi Scopus
2-s2.0-85074412693