Mitochondria-targeted compounds in the treatment of cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43919920" target="_blank" >RIV/00216208:11120/20:43919920 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.4149/neo_2020_190725N671" target="_blank" >https://doi.org/10.4149/neo_2020_190725N671</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2020_190725N671" target="_blank" >10.4149/neo_2020_190725N671</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondria-targeted compounds in the treatment of cancer

Popis výsledku v původním jazyce

Mitochondria are highly dynamic organelles involved in many cellular functions. Beyond their central role in metabolism, they also take a part in maintaining calcium homeostasis, cell death, immunity and ROS production. Changes in these functions have been shown to be crucial for the adaptation and survival of cancer cells. Mitochondria therefore constitute a promising target for the development of novel anticancer agents. The triphenylphosphonium (TPP+) moiety has been widely used to target molecules into mitochondria. TPP+ derivatives of a variety of conventional cytostatic drugs, natural substances, metformin, antioxidants or a range of newly synthesized molecules have shown promising results against cancer cells. In this review we discuss biochemical differences between cancer cells and normal cells with specific focus on mitochondria, and how mitochondrially targeted molecules can be used to selectively affect mitochondrial function in normal and cancer cells. We summarize the published data on mitochondrially targeted anticancer agents and propose future research avenues.

Název v anglickém jazyce

Mitochondria-targeted compounds in the treatment of cancer

Popis výsledku anglicky

Mitochondria are highly dynamic organelles involved in many cellular functions. Beyond their central role in metabolism, they also take a part in maintaining calcium homeostasis, cell death, immunity and ROS production. Changes in these functions have been shown to be crucial for the adaptation and survival of cancer cells. Mitochondria therefore constitute a promising target for the development of novel anticancer agents. The triphenylphosphonium (TPP+) moiety has been widely used to target molecules into mitochondria. TPP+ derivatives of a variety of conventional cytostatic drugs, natural substances, metformin, antioxidants or a range of newly synthesized molecules have shown promising results against cancer cells. In this review we discuss biochemical differences between cancer cells and normal cells with specific focus on mitochondria, and how mitochondrially targeted molecules can be used to selectively affect mitochondrial function in normal and cancer cells. We summarize the published data on mitochondrially targeted anticancer agents and propose future research avenues.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

—

Svazek periodika

67

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

11

Strana od-do

450-460

Kód UT WoS článku

000542668500002

EID výsledku v databázi Scopus

2-s2.0-85084916388