Cerebral oxygenation reflects fetal development in preterm monochorionic and dichorionic twins

Kód výsledku v IS VaVaI

RIV/00216208:11120/20:43920066 - isvavai.cz

Nalezeny alternativní kódy

RIV/00023698:_____/20:N0000017

Výsledek na webu

https://doi.org/10.1016/j.earlhumdev.2020.105025

DOI - Digital Object Identifier

10.1016/j.earlhumdev.2020.105025

Jazyk výsledku

angličtina

Název v původním jazyce

Cerebral oxygenation reflects fetal development in preterm monochorionic and dichorionic twins

Popis výsledku v původním jazyce

Background: Cerebral oxygenation (crSO2) monitoring is increasingly used in high-risk infants. Monochorionic twins suffer from specific fetal pathologies that can affect cerebral hemodynamics. Limited data are available on crSO2 and blood flow patterns in this population after birth. Objective: To evaluate crSO2 changes in preterm monochorionic and dichorionic twins during the first 72 h of life. Methods: Near-infrared spectroscopy was used to measure crSO2 in 62 infants from 31 twin pregnancies <32 weeks of gestation. The study group was divided into 4 subgroups: donor (1) and recipient (2) monochorionic twins (with twin-twin transfusion syndrome), fetal growth restriction (FGR) infants (3) and twins without fetal compromise (4). Results: There was significant difference in birth weight (p < 0.001) among 4 subgroups. We observed significant variation in crSO2 among the subgroups using mixed model analysis (p < 0.001). The recipient twins exhibited the lowest crSO2 (mean +- SE) throughout the study period (76 +- 0.3%), whereas the FGR and donor twins presented with the highest values (86 +- 0.3% and 83 +- 0.4% respectively). We found no statistically significant differences in neonatal mortality and morbidity among subgroups. Conclusion: Our study revealed significant correlation between crSO2 values postnatally and underlying fetal pathology in monochorionic and dichorionic preterm twins.

Název v anglickém jazyce

Cerebral oxygenation reflects fetal development in preterm monochorionic and dichorionic twins

Popis výsledku anglicky

Background: Cerebral oxygenation (crSO2) monitoring is increasingly used in high-risk infants. Monochorionic twins suffer from specific fetal pathologies that can affect cerebral hemodynamics. Limited data are available on crSO2 and blood flow patterns in this population after birth. Objective: To evaluate crSO2 changes in preterm monochorionic and dichorionic twins during the first 72 h of life. Methods: Near-infrared spectroscopy was used to measure crSO2 in 62 infants from 31 twin pregnancies <32 weeks of gestation. The study group was divided into 4 subgroups: donor (1) and recipient (2) monochorionic twins (with twin-twin transfusion syndrome), fetal growth restriction (FGR) infants (3) and twins without fetal compromise (4). Results: There was significant difference in birth weight (p < 0.001) among 4 subgroups. We observed significant variation in crSO2 among the subgroups using mixed model analysis (p < 0.001). The recipient twins exhibited the lowest crSO2 (mean +- SE) throughout the study period (76 +- 0.3%), whereas the FGR and donor twins presented with the highest values (86 +- 0.3% and 83 +- 0.4% respectively). We found no statistically significant differences in neonatal mortality and morbidity among subgroups. Conclusion: Our study revealed significant correlation between crSO2 values postnatally and underlying fetal pathology in monochorionic and dichorionic preterm twins.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Early Human Development

ISSN

0378-3782

e-ISSN

—

Svazek periodika

144

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

"Article 105025"

Kód UT WoS článku

000538595900012

EID výsledku v databázi Scopus

2-s2.0-85082939995