The potential value of histological analysis of thrombi extracted through mechanical thrombectomy during acute ischemic stroke treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920126" target="_blank" >RIV/00216208:11120/20:43920126 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064173:_____/20:N0000099

Výsledek na webu

<a href="https://doi.org/10.14744/AnatolJCardiol.2020.81342" target="_blank" >https://doi.org/10.14744/AnatolJCardiol.2020.81342</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14744/AnatolJCardiol.2020.81342" target="_blank" >10.14744/AnatolJCardiol.2020.81342</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The potential value of histological analysis of thrombi extracted through mechanical thrombectomy during acute ischemic stroke treatment

Popis výsledku v původním jazyce

Studies on thrombus composition in acute stroke or acute myocardial infarction may help elucidate clot etiology and understand reperfusion success or failure. Moreover, such studies may certainly aid in the development of new technologies aimed at retrieving specific subtypes of thrombi; as a matter of fact, thrombus composition is suggested to influence the choice of techniques used during mechanical thrombectomy and plays a role in potential device and thrombus interaction. Over the years, histological analysis on the composition of thrombi causing ischemic stroke has proved to be a powerful tool to set standard prevention and treatment protocols. By isolating clot components, it is possible to provide a more accurate diagnosis and distinguish different stroke subtypes. Studies on histological clot composition support the theory that cryptogenic stroke can have a cardiogenic origin too. Components found in thrombi extracted from stroke patients support the importance of antithrombotic therapy in preventing and treating cerebral ischemia; however, more studies are needed to improve results in all types and subtypes of stroke. Hence, more research is required to further comprehend the role that platelets, fibrin, von Willebrand factor (vWF), and DNA play in relation to mechanical thrombectomy and recombinant tissue plasminogen activator (rtPA) resistance and to overcome certain limitations.

Název v anglickém jazyce

The potential value of histological analysis of thrombi extracted through mechanical thrombectomy during acute ischemic stroke treatment

Popis výsledku anglicky

Studies on thrombus composition in acute stroke or acute myocardial infarction may help elucidate clot etiology and understand reperfusion success or failure. Moreover, such studies may certainly aid in the development of new technologies aimed at retrieving specific subtypes of thrombi; as a matter of fact, thrombus composition is suggested to influence the choice of techniques used during mechanical thrombectomy and plays a role in potential device and thrombus interaction. Over the years, histological analysis on the composition of thrombi causing ischemic stroke has proved to be a powerful tool to set standard prevention and treatment protocols. By isolating clot components, it is possible to provide a more accurate diagnosis and distinguish different stroke subtypes. Studies on histological clot composition support the theory that cryptogenic stroke can have a cardiogenic origin too. Components found in thrombi extracted from stroke patients support the importance of antithrombotic therapy in preventing and treating cerebral ischemia; however, more studies are needed to improve results in all types and subtypes of stroke. Hence, more research is required to further comprehend the role that platelets, fibrin, von Willebrand factor (vWF), and DNA play in relation to mechanical thrombectomy and recombinant tissue plasminogen activator (rtPA) resistance and to overcome certain limitations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anatolian Journal of Cardiology

ISSN

2149-2263

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

TR - Turecká republika

Počet stran výsledku

6

Strana od-do

254-259

Kód UT WoS článku

000535232600005

EID výsledku v databázi Scopus

2-s2.0-85084932262