Prediction of the need for phototherapy during hospital stay in preterm infants by transcutaneous bilirubinometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920254" target="_blank" >RIV/00216208:11120/20:43920254 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023698:_____/20:N0000025

Výsledek na webu

<a href="https://doi.org/10.1016/j.earlhumdev.2020.105029" target="_blank" >https://doi.org/10.1016/j.earlhumdev.2020.105029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.earlhumdev.2020.105029" target="_blank" >10.1016/j.earlhumdev.2020.105029</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prediction of the need for phototherapy during hospital stay in preterm infants by transcutaneous bilirubinometry

Popis výsledku v původním jazyce

Background: Neonatal hyperbilirubinemia is a common condition that frequently requires treatment with phototherapy and less commonly by exchange transfusion, especially in preterm infants. It is important to identify and monitor infants at risk of severe unconjugated hyperbilirubinemia early in the postnatal period to instigate appropriate management plans. Aims: To evaluate transcutaneous bilirubinometry (TCB) as a screening tool at 24 and 48 h of age to predict the need for phototherapy during hospital stay in preterm infants. Study design: A single centre prospective cohort study in a level III perinatal centre. Subjects: Preterm infants (23(+0) to 36(+6) weeks of gestation) were eligible for enrolment. Outcome measures: Primary outcome was to assess the predictive value of TCB at 24 and 48 h of age for the need of phototherapy during hospital stay. Results: A total of 338 preterm infants were enrolled. The majority of infants (98.1%) born below 32 weeks of gestation required phototherapy. For infants born at &gt; 31 + 6 weeks of gestation, TCB at 24 h of age &gt;= 81 mu mol/l had sensitivity 83%, specificity 56%, positive predictive value (PPV) 54.7% and negative predictive value (NPV) 84%. TCB at 48 h of age &gt;= 145 mu mol/l had sensitivity 65%, specificity 62%, PPV 24% and NPV 90%. Conclusion: TCB performed poorly at 24 and 48 h of age as a predictor of phototherapy during hospital stay in preterm infants. The negative predictive value of the test at 48 h of age might be helpful for infants born after 31 + 6 weeks of gestation.

Název v anglickém jazyce

Prediction of the need for phototherapy during hospital stay in preterm infants by transcutaneous bilirubinometry

Popis výsledku anglicky

Background: Neonatal hyperbilirubinemia is a common condition that frequently requires treatment with phototherapy and less commonly by exchange transfusion, especially in preterm infants. It is important to identify and monitor infants at risk of severe unconjugated hyperbilirubinemia early in the postnatal period to instigate appropriate management plans. Aims: To evaluate transcutaneous bilirubinometry (TCB) as a screening tool at 24 and 48 h of age to predict the need for phototherapy during hospital stay in preterm infants. Study design: A single centre prospective cohort study in a level III perinatal centre. Subjects: Preterm infants (23(+0) to 36(+6) weeks of gestation) were eligible for enrolment. Outcome measures: Primary outcome was to assess the predictive value of TCB at 24 and 48 h of age for the need of phototherapy during hospital stay. Results: A total of 338 preterm infants were enrolled. The majority of infants (98.1%) born below 32 weeks of gestation required phototherapy. For infants born at &gt; 31 + 6 weeks of gestation, TCB at 24 h of age &gt;= 81 mu mol/l had sensitivity 83%, specificity 56%, positive predictive value (PPV) 54.7% and negative predictive value (NPV) 84%. TCB at 48 h of age &gt;= 145 mu mol/l had sensitivity 65%, specificity 62%, PPV 24% and NPV 90%. Conclusion: TCB performed poorly at 24 and 48 h of age as a predictor of phototherapy during hospital stay in preterm infants. The negative predictive value of the test at 48 h of age might be helpful for infants born after 31 + 6 weeks of gestation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Early Human Development

ISSN

0378-3782

e-ISSN

—

Svazek periodika

146

Číslo periodika v rámci svazku

July

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

"Article 105029"

Kód UT WoS článku

000539266000009

EID výsledku v databázi Scopus

2-s2.0-85086346854