Predictors of exercise capacity in patients with atrial correction of transposition of great arteries

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920343" target="_blank" >RIV/00216208:11120/20:43920343 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/20:10413089 RIV/00064203:_____/20:10413089

Výsledek na webu

<a href="https://doi.org/10.4149/BLL_2020_087" target="_blank" >https://doi.org/10.4149/BLL_2020_087</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2020_087" target="_blank" >10.4149/BLL_2020_087</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Predictors of exercise capacity in patients with atrial correction of transposition of great arteries

Popis výsledku v původním jazyce

OBJECTIVES: To examine the relationship of clinical, biochemical and imaging parameters to maximum oxygen uptake in patients after atrial correction of transposition of great arteries. BACKGROUND: Exercise tolerance is a key determinant of quality of life in patients with adult congenital heart disease. It is determined by a large scale of factors often different from general cardiology. METHODS: 86 consecutive patients after Senning correction of TGA were subjected to clinical and echocardiographic examination, Holter monitoring, blood tests of NT-proBNP, MRI of the heart and exercise test. Parameters of these examinations were correlated to VO2 max. RESULTS: The average age of patients was 28+-3.5 years. The average systemic right ventricular function determined by MRI was 51.9+-7.9 %. The average NT-proBPN was 124.3+-23.6 ng/l, VO2 max. 31.7+-6.5 ml/kg/min and the heart rate reserve 106+-24 /min. Neither systemic right ventricular systolic function nor NT-proBPN predicted VO2 max., whereas the heart rate reserve did (p=0.003). CONCLUSION: An inability to increase heart rate during exercise noted in a considerable number of patients after atrial switch of TGA caused a decreased exercise tolerance. It is not solely the global systolic function of either ventricle that infl uences the exercise performance, rather it is the ability to increase heart rate and overall cardiac output appropriately (Tab. 3, Fig. 6, Ref. 28).

Název v anglickém jazyce

Predictors of exercise capacity in patients with atrial correction of transposition of great arteries

Popis výsledku anglicky

OBJECTIVES: To examine the relationship of clinical, biochemical and imaging parameters to maximum oxygen uptake in patients after atrial correction of transposition of great arteries. BACKGROUND: Exercise tolerance is a key determinant of quality of life in patients with adult congenital heart disease. It is determined by a large scale of factors often different from general cardiology. METHODS: 86 consecutive patients after Senning correction of TGA were subjected to clinical and echocardiographic examination, Holter monitoring, blood tests of NT-proBNP, MRI of the heart and exercise test. Parameters of these examinations were correlated to VO2 max. RESULTS: The average age of patients was 28+-3.5 years. The average systemic right ventricular function determined by MRI was 51.9+-7.9 %. The average NT-proBPN was 124.3+-23.6 ng/l, VO2 max. 31.7+-6.5 ml/kg/min and the heart rate reserve 106+-24 /min. Neither systemic right ventricular systolic function nor NT-proBPN predicted VO2 max., whereas the heart rate reserve did (p=0.003). CONCLUSION: An inability to increase heart rate during exercise noted in a considerable number of patients after atrial switch of TGA caused a decreased exercise tolerance. It is not solely the global systolic function of either ventricle that infl uences the exercise performance, rather it is the ability to increase heart rate and overall cardiac output appropriately (Tab. 3, Fig. 6, Ref. 28).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/NT13408" target="_blank" >NT13408: Dlouhodobé výsledky Senningovy operace transpozice velkých tepen</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavské lekárske listy / Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

—

Svazek periodika

121

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

6

Strana od-do

527-532

Kód UT WoS článku

000571574800001

EID výsledku v databázi Scopus

2-s2.0-85088841931