Exercise training reduces inflammation of adipose tissue in the elderly: cross-sectional and randomized interventional trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F20%3A43920498" target="_blank" >RIV/00216208:11120/20:43920498 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11510/20:10415974 RIV/00064173:_____/20:N0000040

Výsledek na webu

<a href="https://doi.org/10.1210/clinem/dgaa630" target="_blank" >https://doi.org/10.1210/clinem/dgaa630</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/clinem/dgaa630" target="_blank" >10.1210/clinem/dgaa630</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exercise training reduces inflammation of adipose tissue in the elderly: cross-sectional and randomized interventional trial

Popis výsledku v původním jazyce

CONTEXT: Metabolic disturbances and a pro-inflammatory state associated with aging and obesity may be mitigated by physical activity or nutrition interventions. OBJECTIVE: The aim of this study is to assess whether physical fitness/exercise training (ET) alleviates inflammation in adipose tissue (AT), particularly in combination with omega-3 supplementation, and whether changes in AT induced by ET can contribute to an improvement of insulin sensitivity (IS) and metabolic health in the elderly. DESIGN, PARTICIPANTS, MAIN OUTCOME MEASURES: The effect of physical fitness was determined in cross-sectional comparison of Trained and Untrained older women (71+-4 years, n=48); and in double-blind randomized intervention by 4 months of ET with or without omega-3 (Calanus oil) supplementation (n=55). Physical fitness was evaluated by Spiroergometry (maximum graded exercise test) and Senior Fitness Tests. IS was measured by hyperinsulinemic-euglycemic clamp. Samples of subcutaneous AT were used to analyze mRNA gene expression, cytokine secretion and immune cell populations. RESULTS: Trained women had lower mRNA levels of inflammation and oxidative stress markers, lower relative content of CD36+ macrophages and higher relative content of γδT-cells in AT when compared to Untrained women. Similar effects were recapitulated in response to a 4-month ET intervention. Content of CD36+ cells, γδT-cells and mRNA expression of several inflammatory and oxidative-stress markers correlated to IS and cardiorespiratory fitness. CONCLUSIONS: In older women, physical fitness is associated with less inflammation in AT. This may contribute to beneficial metabolic outcomes achieved by ET. When combined with ET, omega-3 supplementation had no additional beneficial effects on AT inflammatory characteristics.

Název v anglickém jazyce

Exercise training reduces inflammation of adipose tissue in the elderly: cross-sectional and randomized interventional trial

Popis výsledku anglicky

CONTEXT: Metabolic disturbances and a pro-inflammatory state associated with aging and obesity may be mitigated by physical activity or nutrition interventions. OBJECTIVE: The aim of this study is to assess whether physical fitness/exercise training (ET) alleviates inflammation in adipose tissue (AT), particularly in combination with omega-3 supplementation, and whether changes in AT induced by ET can contribute to an improvement of insulin sensitivity (IS) and metabolic health in the elderly. DESIGN, PARTICIPANTS, MAIN OUTCOME MEASURES: The effect of physical fitness was determined in cross-sectional comparison of Trained and Untrained older women (71+-4 years, n=48); and in double-blind randomized intervention by 4 months of ET with or without omega-3 (Calanus oil) supplementation (n=55). Physical fitness was evaluated by Spiroergometry (maximum graded exercise test) and Senior Fitness Tests. IS was measured by hyperinsulinemic-euglycemic clamp. Samples of subcutaneous AT were used to analyze mRNA gene expression, cytokine secretion and immune cell populations. RESULTS: Trained women had lower mRNA levels of inflammation and oxidative stress markers, lower relative content of CD36+ macrophages and higher relative content of γδT-cells in AT when compared to Untrained women. Similar effects were recapitulated in response to a 4-month ET intervention. Content of CD36+ cells, γδT-cells and mRNA expression of several inflammatory and oxidative-stress markers correlated to IS and cardiorespiratory fitness. CONCLUSIONS: In older women, physical fitness is associated with less inflammation in AT. This may contribute to beneficial metabolic outcomes achieved by ET. When combined with ET, omega-3 supplementation had no additional beneficial effects on AT inflammatory characteristics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV16-29182A" target="_blank" >NV16-29182A: Vliv pohybové aktivity a omega-3 mastných kyselin na metabolické zdraví a dysfunkci tukové tkáně u seniorů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Endocrinology &amp; Metabolism

ISSN

0021-972X

e-ISSN

—

Svazek periodika

105

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

17

Strana od-do

"e4510"-"e4526"

Kód UT WoS článku

000584547800059

EID výsledku v databázi Scopus

2-s2.0-85092682327