Oxysterols in Cancer Management: From Therapy to Biomarkers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43920613" target="_blank" >RIV/00216208:11120/21:43920613 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/75010330:_____/21:00013531 RIV/00216208:11140/21:10414523

Výsledek na webu

<a href="https://doi.org/10.1111/bph.15273" target="_blank" >https://doi.org/10.1111/bph.15273</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bph.15273" target="_blank" >10.1111/bph.15273</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Oxysterols in Cancer Management: From Therapy to Biomarkers

Popis výsledku v původním jazyce

Oxysterols are oxidized derivatives of cholesterol, both endogenous and exogenous. They have been implicated in numerous pathologies, including cancer. In addition to their roles in carcinogenesis, proliferation, migration, apoptosis and multiple signalling pathways, they have been shown to modulate cancer therapy. They are known to affect therapy of hormonally positive breast cancer through modulating estrogen receptor activity. Oxysterols have also been shown in various in vitro models to influence efficacy of chemotherapeutics, such as doxorubicin, vincristine, cisplatin, 5-fluorouracil, and others. Their effects on the immune system should also be considered in immunotherapy. Selective anti-cancer cytotoxic properties of some oxysterols make them candidates for new therapeutic molecules. Finally, differences in oxysterol levels in blood of cancer patients in different stages or vs healthy controls, and in tumour vs non-tumour tissues, show potential of oxysterols as biomarkers for cancer management and patient stratification for optimization of therapy.

Název v anglickém jazyce

Oxysterols in Cancer Management: From Therapy to Biomarkers

Popis výsledku anglicky

Oxysterols are oxidized derivatives of cholesterol, both endogenous and exogenous. They have been implicated in numerous pathologies, including cancer. In addition to their roles in carcinogenesis, proliferation, migration, apoptosis and multiple signalling pathways, they have been shown to modulate cancer therapy. They are known to affect therapy of hormonally positive breast cancer through modulating estrogen receptor activity. Oxysterols have also been shown in various in vitro models to influence efficacy of chemotherapeutics, such as doxorubicin, vincristine, cisplatin, 5-fluorouracil, and others. Their effects on the immune system should also be considered in immunotherapy. Selective anti-cancer cytotoxic properties of some oxysterols make them candidates for new therapeutic molecules. Finally, differences in oxysterol levels in blood of cancer patients in different stages or vs healthy controls, and in tumour vs non-tumour tissues, show potential of oxysterols as biomarkers for cancer management and patient stratification for optimization of therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/NV17-28470A" target="_blank" >NV17-28470A: Význam markerů oxysterolové dráhy pro hormonální terapii karcinomu prsu</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British Journal of Pharmacology

ISSN

0007-1188

e-ISSN

—

Svazek periodika

178

Číslo periodika v rámci svazku

16

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

3235-3247

Kód UT WoS článku

000579596000001

EID výsledku v databázi Scopus

2-s2.0-85092889915