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Comparing Ventricular Synchrony in Left Bundle Branch and Left Ventricular Septal Pacing in Pacemaker Patients

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43921227" target="_blank" >RIV/00216208:11120/21:43921227 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216305:26220/21:PU141455 RIV/00064173:_____/21:N0000079 RIV/68081731:_____/21:00559959

  • Výsledek na webu

    <a href="https://doi.org/10.3390/jcm10040822" target="_blank" >https://doi.org/10.3390/jcm10040822</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/jcm10040822" target="_blank" >10.3390/jcm10040822</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Comparing Ventricular Synchrony in Left Bundle Branch and Left Ventricular Septal Pacing in Pacemaker Patients

  • Popis výsledku v původním jazyce

    BACKGROUND: Left bundle branch area pacing (LBBAP) has recently been introduced as a novel physiological pacing strategy. Within LBBAP, distinction is made between left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP, no left bundle capture). OBJECTIVE: To investigate acute electrophysiological effects of LBBP and LVSP as compared to intrinsic ventricular conduction. METHODS: Fifty patients with normal cardiac function and pacemaker indication for bradycardia underwent LBBAP. Electrocardiography (ECG) characteristics were evaluated during pacing at various depths within the septum: starting at the right ventricular (RV) side of the septum: the last position with QS morphology, the first position with r&apos; morphology, LVSP and-in patients where left bundle branch (LBB) capture was achieved-LBBP. From the ECG&apos;s QRS duration and QRS morphology in lead V1, the stimulus- left ventricular activation time left ventricular activation time (LVAT) interval were measured. After conversion of the ECG into vectorcardiogram (VCG) (Kors conversion matrix), QRS area and QRS vector in transverse plane (Azimuth) were determined. RESULTS: QRS area significantly decreased from 82 +- 29 µVs during RV septal pacing (RVSP) to 46 +- 12 µVs during LVSP. In the subgroup where LBB capture was achieved (n = 31), QRS area significantly decreased from 46 +- 17 µVs during LVSP to 38 +- 15 µVs during LBBP, while LVAT was not significantly different between LVSP and LBBP. In patients with normal ventricular activation and narrow QRS, QRS area during LBBP was not significantly different from that during intrinsic activation (37 +- 16 vs. 35 +- 19 µVs, respectively). The Azimuth significantly changed from RVSP (-46 +- 33o) to LVSP (19 +- 16o) and LBBP (-22 +- 14o). The Azimuth during both LVSP and LBBP were not significantly different from normal ventricular activation. QRS area and LVAT correlated moderately (Spearman&apos;s R = 0.58). CONCLUSIONS: ECG and VCG indices demonstrate that both LVSP and LBBP improve ventricular dyssynchrony considerably as compared to RVSP, to values close to normal ventricular activation. LBBP seems to result in a small, but significant, improvement in ventricular synchrony as compared to LVSP.

  • Název v anglickém jazyce

    Comparing Ventricular Synchrony in Left Bundle Branch and Left Ventricular Septal Pacing in Pacemaker Patients

  • Popis výsledku anglicky

    BACKGROUND: Left bundle branch area pacing (LBBAP) has recently been introduced as a novel physiological pacing strategy. Within LBBAP, distinction is made between left bundle branch pacing (LBBP) and left ventricular septal pacing (LVSP, no left bundle capture). OBJECTIVE: To investigate acute electrophysiological effects of LBBP and LVSP as compared to intrinsic ventricular conduction. METHODS: Fifty patients with normal cardiac function and pacemaker indication for bradycardia underwent LBBAP. Electrocardiography (ECG) characteristics were evaluated during pacing at various depths within the septum: starting at the right ventricular (RV) side of the septum: the last position with QS morphology, the first position with r&apos; morphology, LVSP and-in patients where left bundle branch (LBB) capture was achieved-LBBP. From the ECG&apos;s QRS duration and QRS morphology in lead V1, the stimulus- left ventricular activation time left ventricular activation time (LVAT) interval were measured. After conversion of the ECG into vectorcardiogram (VCG) (Kors conversion matrix), QRS area and QRS vector in transverse plane (Azimuth) were determined. RESULTS: QRS area significantly decreased from 82 +- 29 µVs during RV septal pacing (RVSP) to 46 +- 12 µVs during LVSP. In the subgroup where LBB capture was achieved (n = 31), QRS area significantly decreased from 46 +- 17 µVs during LVSP to 38 +- 15 µVs during LBBP, while LVAT was not significantly different between LVSP and LBBP. In patients with normal ventricular activation and narrow QRS, QRS area during LBBP was not significantly different from that during intrinsic activation (37 +- 16 vs. 35 +- 19 µVs, respectively). The Azimuth significantly changed from RVSP (-46 +- 33o) to LVSP (19 +- 16o) and LBBP (-22 +- 14o). The Azimuth during both LVSP and LBBP were not significantly different from normal ventricular activation. QRS area and LVAT correlated moderately (Spearman&apos;s R = 0.58). CONCLUSIONS: ECG and VCG indices demonstrate that both LVSP and LBBP improve ventricular dyssynchrony considerably as compared to RVSP, to values close to normal ventricular activation. LBBP seems to result in a small, but significant, improvement in ventricular synchrony as compared to LVSP.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30201 - Cardiac and Cardiovascular systems

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of Clinical Medicine

  • ISSN

    2077-0383

  • e-ISSN

  • Svazek periodika

    10

  • Číslo periodika v rámci svazku

    4

  • Stát vydavatele periodika

    CH - Švýcarská konfederace

  • Počet stran výsledku

    12

  • Strana od-do

    822

  • Kód UT WoS článku

    000624037000001

  • EID výsledku v databázi Scopus

    2-s2.0-85114081648