The omega of TRPM7 channels in trigeminal neuralgia
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F22%3A43924030" target="_blank" >RIV/00216208:11120/22:43924030 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1007/s00424-022-02757-w" target="_blank" >https://doi.org/10.1007/s00424-022-02757-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00424-022-02757-w" target="_blank" >10.1007/s00424-022-02757-w</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The omega of TRPM7 channels in trigeminal neuralgia
Popis výsledku v původním jazyce
Trigeminal neuralgia (TN), traditionally referred as tic douloureux, is a rare (incidence of about 4 per 100,000 cases per year) form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face [4]. While the etiology of TN is not fully understood, most cases occur in a sporadic manner and are associated with intracranial vascular compression of the trigeminal nerve root that is often assumed to be the pain-initiating mechanism. However, although compression of the trigeminal root appears to be common in the aging population, only few individuals develop TN [7]. Conversely, many TN patients do no show compression of the trigeminal nerve [8]. TN can also occur in a familial manner suggesting the existence of predisposing genetic factors [3]. Whole genome sequencing studies have indeed revealed numerous genetic variants especially in genes encoding ion channels [9]. However, the pathological relevance of ion channel variants in the etiology of TN remains largely unknown.
Název v anglickém jazyce
The omega of TRPM7 channels in trigeminal neuralgia
Popis výsledku anglicky
Trigeminal neuralgia (TN), traditionally referred as tic douloureux, is a rare (incidence of about 4 per 100,000 cases per year) form of chronic neuropathic pain characterized by spontaneous or elicited paroxysms of electric shock-like or stabbing pain in a region of the face [4]. While the etiology of TN is not fully understood, most cases occur in a sporadic manner and are associated with intracranial vascular compression of the trigeminal nerve root that is often assumed to be the pain-initiating mechanism. However, although compression of the trigeminal root appears to be common in the aging population, only few individuals develop TN [7]. Conversely, many TN patients do no show compression of the trigeminal nerve [8]. TN can also occur in a familial manner suggesting the existence of predisposing genetic factors [3]. Whole genome sequencing studies have indeed revealed numerous genetic variants especially in genes encoding ion channels [9]. However, the pathological relevance of ion channel variants in the etiology of TN remains largely unknown.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
30105 - Physiology (including cytology)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů