Comparison of Left Bundle-Branch Area Pacing to Biventricular Pacing in Candidates for Resynchronization Therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F23%3A43925641" target="_blank" >RIV/00216208:11120/23:43925641 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.jacc.2023.05.006" target="_blank" >https://doi.org/10.1016/j.jacc.2023.05.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jacc.2023.05.006" target="_blank" >10.1016/j.jacc.2023.05.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of Left Bundle-Branch Area Pacing to Biventricular Pacing in Candidates for Resynchronization Therapy

Popis výsledku v původním jazyce

BACKGROUND: Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is a well-established therapy in patients with reduced left ventricular ejection fraction (LVEF), heart failure, and wide QRS or expected frequent ventricular pacing. Left bundle branch area pacing (LBBAP) has recently been shown to be a safe alternative to BVP. OBJECTIVE: The aim of this study was to compare the clinical outcomes between BVP and LBBAP among patients undergoing CRT. METHODS: This observational study included patients with LVEFLESS-THAN OR EQUAL TO35% who underwent BVP or LBBAP for the first time for Class I or II indications for CRT between Jan 2018 to June 2022 at 15 international centers. The primary outcome was the composite endpoint of time to death or heart failure hospitalization (HFH). Secondary outcomes included endpoints of death, HFH, and echocardiographic changes. . RESULTS: A total of 1778 patients met inclusion criteria: BVP 981, LBBAP 797. The mean age was 69+-12 years, female 32%, CAD 48%, and LVEF 27+-6%. Paced QRSd in LBBAP was significantly narrower than baseline (128+-19 vs 161+-28ms, p&lt;0.001) and significantly narrower compared to BVP (144+-23ms, p&lt;0.001). Following CRT, LVEF improved from 27+-6% to 41+-13% (p&lt;0.001) with LBBAP compared to an increase from 27+-7% to 37+-12% (p&lt;0.001) with BVP with significantly greater change from baseline with LBBAP (13+-12% vs 10+-12%, p&lt;0.001). On multivariable regression analysis, the primary outcome was significantly reduced with LBBAP compared BVP (20.8% vs 28%; HR 1.495; CI 1.213-1.842; p&lt;0.001). CONCLUSIONS: LBBAP improved clinical outcomes when compared to BVP in patients with CRT indications and may be a reasonable alternative to BVP.

Název v anglickém jazyce

Comparison of Left Bundle-Branch Area Pacing to Biventricular Pacing in Candidates for Resynchronization Therapy

Popis výsledku anglicky

BACKGROUND: Cardiac resynchronization therapy (CRT) with biventricular pacing (BVP) is a well-established therapy in patients with reduced left ventricular ejection fraction (LVEF), heart failure, and wide QRS or expected frequent ventricular pacing. Left bundle branch area pacing (LBBAP) has recently been shown to be a safe alternative to BVP. OBJECTIVE: The aim of this study was to compare the clinical outcomes between BVP and LBBAP among patients undergoing CRT. METHODS: This observational study included patients with LVEFLESS-THAN OR EQUAL TO35% who underwent BVP or LBBAP for the first time for Class I or II indications for CRT between Jan 2018 to June 2022 at 15 international centers. The primary outcome was the composite endpoint of time to death or heart failure hospitalization (HFH). Secondary outcomes included endpoints of death, HFH, and echocardiographic changes. . RESULTS: A total of 1778 patients met inclusion criteria: BVP 981, LBBAP 797. The mean age was 69+-12 years, female 32%, CAD 48%, and LVEF 27+-6%. Paced QRSd in LBBAP was significantly narrower than baseline (128+-19 vs 161+-28ms, p&lt;0.001) and significantly narrower compared to BVP (144+-23ms, p&lt;0.001). Following CRT, LVEF improved from 27+-6% to 41+-13% (p&lt;0.001) with LBBAP compared to an increase from 27+-7% to 37+-12% (p&lt;0.001) with BVP with significantly greater change from baseline with LBBAP (13+-12% vs 10+-12%, p&lt;0.001). On multivariable regression analysis, the primary outcome was significantly reduced with LBBAP compared BVP (20.8% vs 28%; HR 1.495; CI 1.213-1.842; p&lt;0.001). CONCLUSIONS: LBBAP improved clinical outcomes when compared to BVP in patients with CRT indications and may be a reasonable alternative to BVP.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American College of Cardiology

ISSN

0735-1097

e-ISSN

1558-3597

Svazek periodika

82

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

228-241

Kód UT WoS článku

001041062200001

EID výsledku v databázi Scopus

2-s2.0-85163010359