CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F23%3A43926926" target="_blank" >RIV/00216208:11120/23:43926926 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00134792 RIV/00216208:11110/23:10479301 RIV/00064190:_____/23:10001206 RIV/00023001:_____/23:00084736

Výsledek na webu

<a href="https://doi.org/10.14712/fb2023069050181" target="_blank" >https://doi.org/10.14712/fb2023069050181</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/fb2023069050181" target="_blank" >10.14712/fb2023069050181</a>

Jazyk výsledku

angličtina

Název v původním jazyce

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

Popis výsledku v původním jazyce

A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (CRIGHTWARDS ARROWT; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case-control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2-positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering co-dominant and recessive genetic models or various between-group comparisons. The CD14 polymorphism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.

Název v anglickém jazyce

CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population

Popis výsledku anglicky

A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (CRIGHTWARDS ARROWT; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case-control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2-positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering co-dominant and recessive genetic models or various between-group comparisons. The CD14 polymorphism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Biologica

ISSN

0015-5500

e-ISSN

2533-7602

Svazek periodika

69

Číslo periodika v rámci svazku

5-6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

181-185

Kód UT WoS článku

001199526300002

EID výsledku v databázi Scopus

2-s2.0-85190398441