The Role of Pharmacotherapy in the Management of Comorbidities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F25%3A43928543" target="_blank" >RIV/00216208:11120/25:43928543 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/978-3-031-81802-8_18" target="_blank" >https://doi.org/10.1007/978-3-031-81802-8_18</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-81802-8_18" target="_blank" >10.1007/978-3-031-81802-8_18</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Role of Pharmacotherapy in the Management of Comorbidities

Popis výsledku v původním jazyce

This chapter covers the basic principles of clinical pharmacology, focusing on the elderly and the role of pharmacotherapy in patients with comorbid mental and physical illnesses. Consideration of pharmacokinetic processes (liberation, absorption, distribution, metabolism, and elimination) helps improve the efficacy and safety of pharmacological treatments, especially for patients with comorbidities and polypharmacy. Since drug-drug interactions (DDIs) are a significant source of adverse drug events, the identification of potential DDIs may also contribute to better treatment of patients with comorbidities. Depression and physical comorbidities are discussed in detail in this chapter because depression is one of the most commonly diagnosed psychiatric disorders, and it is highly prevalent in patients with physical illnesses. In addition, the treatment of somatic conditions can induce secondary depression, and antidepressant medications have various somatic adverse effects. These complexities are summarized based on current evidence and specific clinical recommendations to help guide decision-making about the pharmacologic treatment of depression with somatic comorbidities. The short section on schizophrenia with somatic comorbidities emphasizes that, in addition to cardiovascular and metabolic diseases, infectious diseases, particularly pulmonary infections, are linked to higher mortality rates compared to the general population.

Název v anglickém jazyce

The Role of Pharmacotherapy in the Management of Comorbidities

Popis výsledku anglicky

This chapter covers the basic principles of clinical pharmacology, focusing on the elderly and the role of pharmacotherapy in patients with comorbid mental and physical illnesses. Consideration of pharmacokinetic processes (liberation, absorption, distribution, metabolism, and elimination) helps improve the efficacy and safety of pharmacological treatments, especially for patients with comorbidities and polypharmacy. Since drug-drug interactions (DDIs) are a significant source of adverse drug events, the identification of potential DDIs may also contribute to better treatment of patients with comorbidities. Depression and physical comorbidities are discussed in detail in this chapter because depression is one of the most commonly diagnosed psychiatric disorders, and it is highly prevalent in patients with physical illnesses. In addition, the treatment of somatic conditions can induce secondary depression, and antidepressant medications have various somatic adverse effects. These complexities are summarized based on current evidence and specific clinical recommendations to help guide decision-making about the pharmacologic treatment of depression with somatic comorbidities. The short section on schizophrenia with somatic comorbidities emphasizes that, in addition to cardiovascular and metabolic diseases, infectious diseases, particularly pulmonary infections, are linked to higher mortality rates compared to the general population.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Comorbidity between Mental and Physical Disorders: Identification, Management and Treatment

ISBN

978-3-031-81801-1

Počet stran výsledku

20

Strana od-do

411-430

Počet stran knihy

523

Název nakladatele

Springer

Místo vydání

Basel, Cham

Kód UT WoS kapitoly

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