Biomechanics of Arteriovenous Fistula: An Overview of Hemodynamic and Remodeling Mechanisms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F25%3A43929292" target="_blank" >RIV/00216208:11120/25:43929292 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.14712/18059694.2025.25" target="_blank" >https://doi.org/10.14712/18059694.2025.25</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/18059694.2025.25" target="_blank" >10.14712/18059694.2025.25</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biomechanics of Arteriovenous Fistula: An Overview of Hemodynamic and Remodeling Mechanisms

Popis výsledku v původním jazyce

Arteriovenous fistulas (AVFs) are widely accepted as the gold standard for vascular access in chronic hemodialysis patients due to their superior long-term patency and low complication rates. However, up to half of all created AVFs fail to mature adequately, and many develop late complications such as stenosis, thrombosis, or aneurysmal degeneration. This review provides an overview of the AVF development process, focusing on the biomechanical forces that drive vascular remodeling and contribute to maturation and pathological changes. We summarize the role of endothelial mechanotransduction and insights from recent studies that reveal how wall shear stress (WSS) patterns and oscillatory flow relate to the genesis of neointimal hyperplasia and later stenosis. Understanding these mechanobiological processes has led to novel surgical techniques, anastomosis design optimization, and better cannulation strategies. Although the knowledge of hemodynamic-biological interactions remain limited, further research can offer directions for better AVF performance.

Název v anglickém jazyce

Biomechanics of Arteriovenous Fistula: An Overview of Hemodynamic and Remodeling Mechanisms

Popis výsledku anglicky

Arteriovenous fistulas (AVFs) are widely accepted as the gold standard for vascular access in chronic hemodialysis patients due to their superior long-term patency and low complication rates. However, up to half of all created AVFs fail to mature adequately, and many develop late complications such as stenosis, thrombosis, or aneurysmal degeneration. This review provides an overview of the AVF development process, focusing on the biomechanical forces that drive vascular remodeling and contribute to maturation and pathological changes. We summarize the role of endothelial mechanotransduction and insights from recent studies that reveal how wall shear stress (WSS) patterns and oscillatory flow relate to the genesis of neointimal hyperplasia and later stenosis. Understanding these mechanobiological processes has led to novel surgical techniques, anastomosis design optimization, and better cannulation strategies. Although the knowledge of hemodynamic-biological interactions remain limited, further research can offer directions for better AVF performance.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Medica

ISSN

1211-4286

e-ISSN

1805-9694

Svazek periodika

68

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

82-86

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-105026639251