Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of N-G-nitro-L-arginine-methyl ester hypertensive rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F09%3A5310" target="_blank" >RIV/00216208:11130/09:5310 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/09:00330732

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of N-G-nitro-L-arginine-methyl ester hypertensive rats

Popis výsledku v původním jazyce

Objective Melatonin was shown to reduce blood pressure, enhance nitric oxide availability and scavenge free radicals. There is, however, a shortage of data with respect to the effect of melatonin on pathological left ventricular remodelling associated with haemodynamic overload. Design We investigated whether melatonin was able to prevent left ventricular hypertrophy (LVH) and fibrosis associated with N-G-nitro-L-arginine-methyl ester (L-NAME)induced hypertension. Methods Four groups of male Wistar ratswere investigated: control, L-NAME (50 mg/kg per day), melatonin (10 mg/kg per day) and L-NAME plus melatonin. Blood pressure was measured non-invasively each week. After 5 weeks of treatment the animals were killed and nitric oxide synthase (NOS) activity, endothelial and inducible NOS expression, the level of collagenous proteins, hydroxyproline and conjugated dienes in the left ventricle were determined. Results The administration of L-NAME inhibited NOS activity, increased conjugate

Název v anglickém jazyce

Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of N-G-nitro-L-arginine-methyl ester hypertensive rats

Popis výsledku anglicky

Objective Melatonin was shown to reduce blood pressure, enhance nitric oxide availability and scavenge free radicals. There is, however, a shortage of data with respect to the effect of melatonin on pathological left ventricular remodelling associated with haemodynamic overload. Design We investigated whether melatonin was able to prevent left ventricular hypertrophy (LVH) and fibrosis associated with N-G-nitro-L-arginine-methyl ester (L-NAME)induced hypertension. Methods Four groups of male Wistar ratswere investigated: control, L-NAME (50 mg/kg per day), melatonin (10 mg/kg per day) and L-NAME plus melatonin. Blood pressure was measured non-invasively each week. After 5 weeks of treatment the animals were killed and nitric oxide synthase (NOS) activity, endothelial and inducible NOS expression, the level of collagenous proteins, hydroxyproline and conjugated dienes in the left ventricle were determined. Results The administration of L-NAME inhibited NOS activity, increased conjugate

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/GA305%2F08%2F0139" target="_blank" >GA305/08/0139: Poruchy regulace vasoaktivní rovnováhy u experimentální hypertenze</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Hypertension

ISSN

0263-6352

e-ISSN

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Svazek periodika

27

Číslo periodika v rámci svazku

Suppl. 6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000269549400003

EID výsledku v databázi Scopus

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