Fluorescent magnetic nanoparticles for biomedical applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A7084" target="_blank" >RIV/00216208:11130/11:7084 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/11:00359777 RIV/61389013:_____/11:00359777 RIV/00023001:_____/11:00002740

Výsledek na webu

<a href="http://pubs.rsc.org/en/content/articlelanding/2011/jm/c1jm10621j" target="_blank" >http://pubs.rsc.org/en/content/articlelanding/2011/jm/c1jm10621j</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fluorescent magnetic nanoparticles for biomedical applications

Popis výsledku v původním jazyce

The simultaneous combination of optical and magnetic resonance imaging (MRI) would greatly benefit in vivo disease diagnosis as well as in situ monitoring of living cells. In order to design dual detection of cells involving simultaneous imaging by fluorescent microscopy and MRI, nanoparticles with two reporters, a fluorescent dye and a superparamagnetic core, included in one particle were synthesized and characterized. The gamma-Fe2O3 nanoparticles obtained by coprecipitation and oxidation were coatedwith silica (SiO2) or carboxymethyl chitosan (CMCS) and labeled with fluorescein isothiocyanate (FITC). The fluorescent label was covalently bound to the nanoparticles and was not quenched by the iron oxide core. The nanoparticles successfully labeled rat mesenchymal stem cells (rMSCs) in vitro. Relaxation time measurements found large amounts of iron inside the cells with FITC-labeled gamma-Fe2O3-SiO2-AP nanoparticles. Both MR and fluorescent imaging of a rat brain with implanted rMSCs

Název v anglickém jazyce

Fluorescent magnetic nanoparticles for biomedical applications

Popis výsledku anglicky

The simultaneous combination of optical and magnetic resonance imaging (MRI) would greatly benefit in vivo disease diagnosis as well as in situ monitoring of living cells. In order to design dual detection of cells involving simultaneous imaging by fluorescent microscopy and MRI, nanoparticles with two reporters, a fluorescent dye and a superparamagnetic core, included in one particle were synthesized and characterized. The gamma-Fe2O3 nanoparticles obtained by coprecipitation and oxidation were coatedwith silica (SiO2) or carboxymethyl chitosan (CMCS) and labeled with fluorescein isothiocyanate (FITC). The fluorescent label was covalently bound to the nanoparticles and was not quenched by the iron oxide core. The nanoparticles successfully labeled rat mesenchymal stem cells (rMSCs) in vitro. Relaxation time measurements found large amounts of iron inside the cells with FITC-labeled gamma-Fe2O3-SiO2-AP nanoparticles. Both MR and fluorescent imaging of a rat brain with implanted rMSCs

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Chemistry

ISSN

0959-9428

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

7630-7639

Kód UT WoS článku

000290670000017

EID výsledku v databázi Scopus

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