S-Adenosylmethionine does not Reduce Ischaemia-Reperfusion Injury to a Marginal Liver Graft in an In vivo Experiment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F12%3A8018" target="_blank" >RIV/00216208:11130/12:8018 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/12:#0000097

Výsledek na webu

<a href="http://dx.doi.org/10.5754/hge11239" target="_blank" >http://dx.doi.org/10.5754/hge11239</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

S-Adenosylmethionine does not Reduce Ischaemia-Reperfusion Injury to a Marginal Liver Graft in an In vivo Experiment

Popis výsledku v původním jazyce

Background/Aims: There are a limited number of appropriate cadaver liver donors. One possible solution is the use of marginal liver grafts from cadaver donors for liver transplantation. Methodology: Rats with liver steatosis were divided into four containing seven animals steatotic liver grafts; +S-adenosylmethionine; I-b: steatotic liver grafts were transplanted; no S-adenosylmethionine; II-a: normal liver grafts, +S-adenosylmethionine; II-b: normal liver grafts. Blood samples were taken at days -1, 3and 14. Results: ALT values at day 14: 1.75 +/- 1.10 mu kat/L (in group I-a), 1.91 +/- 1.41 mu kat/L (in group I-b), 2.13 +/- 1.85 mu kat/L (in group II-a) and 2.08 +/- 1.35 mu kat/L (in group II-b). There were no significant differences between these values. GSH values at day 14 post-transplantation were: 44.90 +/- 8.61 mu M/ mg (in group I-a), 43.82 +/- 8.58 mu M/mg (in group I-b), 41.65 +/- 4.87 mu M/mg (in group II-a) and 42.71 +/- 4.17 mu M/ mg (in control group II-b). Conclusions:

Název v anglickém jazyce

S-Adenosylmethionine does not Reduce Ischaemia-Reperfusion Injury to a Marginal Liver Graft in an In vivo Experiment

Popis výsledku anglicky

Background/Aims: There are a limited number of appropriate cadaver liver donors. One possible solution is the use of marginal liver grafts from cadaver donors for liver transplantation. Methodology: Rats with liver steatosis were divided into four containing seven animals steatotic liver grafts; +S-adenosylmethionine; I-b: steatotic liver grafts were transplanted; no S-adenosylmethionine; II-a: normal liver grafts, +S-adenosylmethionine; II-b: normal liver grafts. Blood samples were taken at days -1, 3and 14. Results: ALT values at day 14: 1.75 +/- 1.10 mu kat/L (in group I-a), 1.91 +/- 1.41 mu kat/L (in group I-b), 2.13 +/- 1.85 mu kat/L (in group II-a) and 2.08 +/- 1.35 mu kat/L (in group II-b). There were no significant differences between these values. GSH values at day 14 post-transplantation were: 44.90 +/- 8.61 mu M/ mg (in group I-a), 43.82 +/- 8.58 mu M/mg (in group I-b), 41.65 +/- 4.87 mu M/mg (in group II-a) and 42.71 +/- 4.17 mu M/ mg (in control group II-b). Conclusions:

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A065" target="_blank" >LN00A065: Centrum buněčné terapie a tkáňových náhrad</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hepato-Gastroenterology

ISSN

0172-6390

e-ISSN

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Svazek periodika

59

Číslo periodika v rámci svazku

113

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

3

Strana od-do

216-218

Kód UT WoS článku

000301397300050

EID výsledku v databázi Scopus

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