Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F12%3A8288" target="_blank" >RIV/00216208:11130/12:8288 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378041:_____/12:00379338 RIV/61389013:_____/12:00379338 RIV/68378050:_____/12:00379338 RIV/00216208:11120/12:43901656 a 2 dalších
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s10856-012-4577-7" target="_blank" >http://dx.doi.org/10.1007/s10856-012-4577-7</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing
Popis výsledku v původním jazyce
Electrospun gelatin and poly-epsilon-caprolactone (PCL) nanofibers were prepared using needleless technology and their biocompatibility and therapeutic efficacy have been characterized in vitro in cell cultures and in an experimental model of a skin wound. The effect of nanofibers on wound healing was examined using a full thickness wound model in rats and compared with a standard control treatment with gauze. Significantly faster wound closure was found with gelatin after 5 and 10 days of treatment, but no enhancement with PCL nanofibers was observed. Histological analysis revealed enhanced epithelialisation, increased depth of granulation tissue and increased density of myofibroblasts in the wound area with gelatin nanofibers. The results show that gelatin nanofibers produced by needleless technology accelerate wound healing and may be suitable as a scaffold for cell transfer and skin regeneration.
Název v anglickém jazyce
Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing
Popis výsledku anglicky
Electrospun gelatin and poly-epsilon-caprolactone (PCL) nanofibers were prepared using needleless technology and their biocompatibility and therapeutic efficacy have been characterized in vitro in cell cultures and in an experimental model of a skin wound. The effect of nanofibers on wound healing was examined using a full thickness wound model in rats and compared with a standard control treatment with gauze. Significantly faster wound closure was found with gelatin after 5 and 10 days of treatment, but no enhancement with PCL nanofibers was observed. Histological analysis revealed enhanced epithelialisation, increased depth of granulation tissue and increased density of myofibroblasts in the wound area with gelatin nanofibers. The results show that gelatin nanofibers produced by needleless technology accelerate wound healing and may be suitable as a scaffold for cell transfer and skin regeneration.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Materials Science-Materials in Medicine
ISSN
0957-4530
e-ISSN
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Svazek periodika
23
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
11
Strana od-do
931-941
Kód UT WoS článku
000302345400008
EID výsledku v databázi Scopus
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