Short-Term Fasting Reduces the Extent of Myocardial Infarction and Incidence of Reperfusion Arrhythmias in Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F12%3A8557" target="_blank" >RIV/00216208:11130/12:8557 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/12:00389397 RIV/00064203:_____/12:8557

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/61/61_567.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/61/61_567.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Short-Term Fasting Reduces the Extent of Myocardial Infarction and Incidence of Reperfusion Arrhythmias in Rats

Popis výsledku v původním jazyce

The effect of three-day fasting on cardiac ischemic tolerance was investigated in adult male Wistar rats. Anesthetized open-chest animals (pentobarbitone 60 mg/kg, i.p.) were subjected to 20-min left anterior descending coronary artery occlusion and 3-hreperfusion for infarct size determination. Ventricular arrhythmias were monitored during ischemia and at the beginning (3 min) of reperfusion. Myocardial concentrations of beta-hydroxybutyrate and acetoacetate were measured to assess mitochondrial redoxstate. Short-term fasting limited the infarct size (48.5 +/- 3.3 % of the area at risk) compared to controls (74.3 +/- 2.2 %) and reduced the total number of premature ventricular complexes (12.5 +/- 5.8) compared to controls (194.9 +/- 21.9) as well asthe duration of ventricular tachycardia (0.6 +/- 0.4 s vs. 18.8 +/- 2.5 s) occurring at early reperfusion. Additionally, fasting increased the concentration of beta-hydroxybutyrate and beta-hydroxybutyrate/acetoacetate ratio (87.8 +/- 27

Název v anglickém jazyce

Short-Term Fasting Reduces the Extent of Myocardial Infarction and Incidence of Reperfusion Arrhythmias in Rats

Popis výsledku anglicky

The effect of three-day fasting on cardiac ischemic tolerance was investigated in adult male Wistar rats. Anesthetized open-chest animals (pentobarbitone 60 mg/kg, i.p.) were subjected to 20-min left anterior descending coronary artery occlusion and 3-hreperfusion for infarct size determination. Ventricular arrhythmias were monitored during ischemia and at the beginning (3 min) of reperfusion. Myocardial concentrations of beta-hydroxybutyrate and acetoacetate were measured to assess mitochondrial redoxstate. Short-term fasting limited the infarct size (48.5 +/- 3.3 % of the area at risk) compared to controls (74.3 +/- 2.2 %) and reduced the total number of premature ventricular complexes (12.5 +/- 5.8) compared to controls (194.9 +/- 21.9) as well asthe duration of ventricular tachycardia (0.6 +/- 0.4 s vs. 18.8 +/- 2.5 s) occurring at early reperfusion. Additionally, fasting increased the concentration of beta-hydroxybutyrate and beta-hydroxybutyrate/acetoacetate ratio (87.8 +/- 27

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

61

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

567-574

Kód UT WoS článku

000314138600002

EID výsledku v databázi Scopus

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