Nitrites and nitrates in exhaled breath condensate in cystic fibrosis: relation to clinical parameters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209798" target="_blank" >RIV/00216208:11130/13:10209798 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/13:10209798 RIV/00216208:11150/13:10209798

Výsledek na webu

<a href="http://dx.doi.org/10.4149/BLL_2013_105" target="_blank" >http://dx.doi.org/10.4149/BLL_2013_105</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2013_105" target="_blank" >10.4149/BLL_2013_105</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nitrites and nitrates in exhaled breath condensate in cystic fibrosis: relation to clinical parameters

Popis výsledku v původním jazyce

Objectives: To evaluate correlation of exhaled breath condensate (EBC) nitrite and nitrate concentrations with disease severity in cystic fibrosis (CF) patients. Background: Nitrites and nitrates are products of oxidative metabolism of nitric oxide. Impaired metabolism of nitric oxide plays a role in pathogenesis of CF. Methods: EBC was collected from 46 stable CF patients and from 21 healthy controls. EBC concentrations of nitrites and nitrates were correlated with parameters of lung disease and nutritional status and with systemic inflammatory markers. Results: EBC nitrates concentrations in CF patients were lower than in healthy subjects (5.8 vs 14.3 mu mol/l, p<0.001). They correlated positively with FEV1 (p=0.025) and serum albumin values (p=0.016) and negatively with chest radiograph Northern score (p=0.015) and serum C-reactive protein values (p=0.005). EEC nitrites concentrations in CF patients did not differ from those in healthy subjects and were not correlated to any studied

Název v anglickém jazyce

Nitrites and nitrates in exhaled breath condensate in cystic fibrosis: relation to clinical parameters

Popis výsledku anglicky

Objectives: To evaluate correlation of exhaled breath condensate (EBC) nitrite and nitrate concentrations with disease severity in cystic fibrosis (CF) patients. Background: Nitrites and nitrates are products of oxidative metabolism of nitric oxide. Impaired metabolism of nitric oxide plays a role in pathogenesis of CF. Methods: EBC was collected from 46 stable CF patients and from 21 healthy controls. EBC concentrations of nitrites and nitrates were correlated with parameters of lung disease and nutritional status and with systemic inflammatory markers. Results: EBC nitrates concentrations in CF patients were lower than in healthy subjects (5.8 vs 14.3 mu mol/l, p<0.001). They correlated positively with FEV1 (p=0.025) and serum albumin values (p=0.016) and negatively with chest radiograph Northern score (p=0.015) and serum C-reactive protein values (p=0.005). EEC nitrites concentrations in CF patients did not differ from those in healthy subjects and were not correlated to any studied

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FC - Pneumologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NR8304" target="_blank" >NR8304: Význam stanovení markerů zánětu a oxidačního stresu v kondenzátu vydechovaného vzduchu pro progresi cystické fibrózy (CF) a možnosti jejího ovlivnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislavske Lekarske Listy

ISSN

0006-9248

e-ISSN

—

Svazek periodika

114

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

503-507

Kód UT WoS článku

000330327300003

EID výsledku v databázi Scopus

—