Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10210371" target="_blank" >RIV/00216208:11130/13:10210371 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/13:00392836

Výsledek na webu

<a href="http://link.springer.com/chapter/10.1007/978-1-4614-5203-4_6" target="_blank" >http://link.springer.com/chapter/10.1007/978-1-4614-5203-4_6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-1-4614-5203-4_6" target="_blank" >10.1007/978-1-4614-5203-4_6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia

Popis výsledku v původním jazyce

One of the most common insults during early stages of postnatal ontogenetic development is hypoxemia due to cyanotic congenital heart defects. The question of the presumed cardiac impact will be, therefore, of considerable importance. Experimental results have clearly shown that the immature heart is significantly more tolerant to acute oxygen deficiency than the adult myocardium. However, the mechanisms of this difference have not yet been satisfactorily clarified; they are likely the result of developmental changes in cardiac mitochondrial function and energy metabolism. Adaptation to chronic hypoxia confers long-lasting protection in both adult and immature heart. However, the already high resistance of the newborn heart cannot be further increased;the effects of protective mechanisms appear only when the ischemic tolerance starts to decrease during development. Early chronic hypoxia, although transient, may have serious sex-dependent late consequences on the adult cardiovascular s

Název v anglickém jazyce

Ontogenetic Aspects of Cardiac Adaptation to Chronic Hypoxia

Popis výsledku anglicky

One of the most common insults during early stages of postnatal ontogenetic development is hypoxemia due to cyanotic congenital heart defects. The question of the presumed cardiac impact will be, therefore, of considerable importance. Experimental results have clearly shown that the immature heart is significantly more tolerant to acute oxygen deficiency than the adult myocardium. However, the mechanisms of this difference have not yet been satisfactorily clarified; they are likely the result of developmental changes in cardiac mitochondrial function and energy metabolism. Adaptation to chronic hypoxia confers long-lasting protection in both adult and immature heart. However, the already high resistance of the newborn heart cannot be further increased;the effects of protective mechanisms appear only when the ischemic tolerance starts to decrease during development. Early chronic hypoxia, although transient, may have serious sex-dependent late consequences on the adult cardiovascular s

Druh

C - Kapitola v odborné knize

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP303%2F12%2F1162" target="_blank" >GAP303/12/1162: Interakce mezi dlouhodobými formami kardioprotekce vyvolané adaptací na chronickou hypoxii a pravidelnou fyzickou zátěží.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Cardiac Adaptations

ISBN

978-1-4614-5202-7

Počet stran výsledku

12

Strana od-do

99-110

Počet stran knihy

402

Název nakladatele

Springer Science+Bussines

Místo vydání

USA

Kód UT WoS kapitoly

—