Anticonvulsant and behavioral effects of muscimol in immature rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F14%3A10293074" target="_blank" >RIV/00216208:11130/14:10293074 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985823:_____/14:00434399
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.brainres.2014.07.038" target="_blank" >http://dx.doi.org/10.1016/j.brainres.2014.07.038</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.brainres.2014.07.038" target="_blank" >10.1016/j.brainres.2014.07.038</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Anticonvulsant and behavioral effects of muscimol in immature rats
Popis výsledku v původním jazyce
Potentiation of GABAergic inhibition is a mechanism of action of many antiepileptic drugs. The potential use of an agonist of GABA-A receptors, muscimol, as an antiepileptic drug was studied in immature rats by assessing anticonvulsant activity and sideeffects on motor activities. Anticonvulsant action was tested in two models of seizures (pentetrazol-induced convulsions and cortical epileptic afterdischarges). Off target effect on motor performance was assessed in a battery of tests and in the open field in three age groups (12-, 18- and 25-day-old rats). Muscimol was administered in doses from 0.1 to 1 mg/kg i.p. Only the 1 mg/kg dose exhibited marked anticonvulsant effect against pentetrazol-induced convulsions in 12- and 18-day-old rats, proconvulsant effect was observed in the second model in 18- and 25-day-old rats as prolongation of afterdischarges. Even the 0.5 mg/kg dose suppressed spontaneous locomotion and heavily compromised motor performance. The effect on motor activity
Název v anglickém jazyce
Anticonvulsant and behavioral effects of muscimol in immature rats
Popis výsledku anglicky
Potentiation of GABAergic inhibition is a mechanism of action of many antiepileptic drugs. The potential use of an agonist of GABA-A receptors, muscimol, as an antiepileptic drug was studied in immature rats by assessing anticonvulsant activity and sideeffects on motor activities. Anticonvulsant action was tested in two models of seizures (pentetrazol-induced convulsions and cortical epileptic afterdischarges). Off target effect on motor performance was assessed in a battery of tests and in the open field in three age groups (12-, 18- and 25-day-old rats). Muscimol was administered in doses from 0.1 to 1 mg/kg i.p. Only the 1 mg/kg dose exhibited marked anticonvulsant effect against pentetrazol-induced convulsions in 12- and 18-day-old rats, proconvulsant effect was observed in the second model in 18- and 25-day-old rats as prolongation of afterdischarges. Even the 0.5 mg/kg dose suppressed spontaneous locomotion and heavily compromised motor performance. The effect on motor activity
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP304%2F10%2F1274" target="_blank" >GAP304/10/1274: Látky ovlivňující GABA-B receptory v pediatrických oborech</a><br>
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Brain Research
ISSN
0006-8993
e-ISSN
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Svazek periodika
1582
Číslo periodika v rámci svazku
neuveden
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
10
Strana od-do
227-236
Kód UT WoS článku
000343357100022
EID výsledku v databázi Scopus
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