Role of Kv7 channels in responses of the pulmonary circulation to hypoxia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294584" target="_blank" >RIV/00216208:11130/15:10294584 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/15:10294584 RIV/27283933:_____/15:N0000011

Výsledek na webu

<a href="http://dx.doi.org/10.1152/ajplung.00362.2013" target="_blank" >http://dx.doi.org/10.1152/ajplung.00362.2013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1152/ajplung.00362.2013" target="_blank" >10.1152/ajplung.00362.2013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of Kv7 channels in responses of the pulmonary circulation to hypoxia

Popis výsledku v původním jazyce

Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia are associated with depolarization of smooth muscle cells in the pulmonary arteries and reduced activity of K+ channels. As Kv7 channels have been proposed to play a key role in regulating the smooth muscle membrane potential, we investigated their involvement in the development of HPV and hypoxia-induced pulmonary hypertension. Vascular effects of the selective Kv7 blocker, linopirdine, and Kv7 activator, flupirtine, were investigated in isolated, saline-perfused lungs from rats maintained for 3-5days in an isobaric hypoxic chamber (FIO2 = 0.1) or room air. Linopirdine increased vascular resistance in lungs from normoxic, but not hypoxic rats. This effect was associated with reduced mRNA expression of the Kv7.4 channel alpha-subun

Název v anglickém jazyce

Role of Kv7 channels in responses of the pulmonary circulation to hypoxia

Popis výsledku anglicky

Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia are associated with depolarization of smooth muscle cells in the pulmonary arteries and reduced activity of K+ channels. As Kv7 channels have been proposed to play a key role in regulating the smooth muscle membrane potential, we investigated their involvement in the development of HPV and hypoxia-induced pulmonary hypertension. Vascular effects of the selective Kv7 blocker, linopirdine, and Kv7 activator, flupirtine, were investigated in isolated, saline-perfused lungs from rats maintained for 3-5days in an isobaric hypoxic chamber (FIO2 = 0.1) or room air. Linopirdine increased vascular resistance in lungs from normoxic, but not hypoxic rats. This effect was associated with reduced mRNA expression of the Kv7.4 channel alpha-subun

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Physiology - Lung Cellular and Molecular Physiology

ISSN

1040-0605

e-ISSN

—

Svazek periodika

308

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

"L48"-"L57"

Kód UT WoS článku

000347230700005

EID výsledku v databázi Scopus

2-s2.0-84920260955