White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295045" target="_blank" >RIV/00216208:11130/15:10295045 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/15:00062868 RIV/00064203:_____/15:10295045

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.007" target="_blank" >http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.007" target="_blank" >10.1016/j.neurobiolaging.2015.03.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging

Popis výsledku v původním jazyce

Many patients with dementia with Lewy bodies (DLB) have overlapping Alzheimer's disease (AD) erelated pathology, which may contribute to white matter (WM) diffusivity alterations on diffusion tensor imaging (DTI). Consecutive patients with DLB (n = 30),age-and sex-matched AD patients (n = 30), and cognitively normal controls (n = 60) were recruited. All subjects underwent DTI, 18F 2-fluoro-deoxy-D-glucose, and C-11 Pittsburgh compound B positron emission tomography scans. DLB patients had reduced fractional anisotropy (FA) in the parietooccipital WM but not elsewhere compared with cognitively normal controls, and elevated FA in parahippocampal WM compared with AD patients, which persisted after controlling for b-amyloid load in DLB. The pattern of WMFA alterations on DTI was consistent with the more diffuse posterior parietal and occipital glucose hypometabolism of 2-fluoro-deoxy-D-glucose positron emission tomography in the cortex. DLB is characterized by a loss of parietooccipital

Název v anglickém jazyce

White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging

Popis výsledku anglicky

Many patients with dementia with Lewy bodies (DLB) have overlapping Alzheimer's disease (AD) erelated pathology, which may contribute to white matter (WM) diffusivity alterations on diffusion tensor imaging (DTI). Consecutive patients with DLB (n = 30),age-and sex-matched AD patients (n = 30), and cognitively normal controls (n = 60) were recruited. All subjects underwent DTI, 18F 2-fluoro-deoxy-D-glucose, and C-11 Pittsburgh compound B positron emission tomography scans. DLB patients had reduced fractional anisotropy (FA) in the parietooccipital WM but not elsewhere compared with cognitively normal controls, and elevated FA in parahippocampal WM compared with AD patients, which persisted after controlling for b-amyloid load in DLB. The pattern of WMFA alterations on DTI was consistent with the more diffuse posterior parietal and occipital glucose hypometabolism of 2-fluoro-deoxy-D-glucose positron emission tomography in the cortex. DLB is characterized by a loss of parietooccipital

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurobiology of Aging

ISSN

0197-4580

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

2010-2017

Kód UT WoS článku

000355378600002

EID výsledku v databázi Scopus

2-s2.0-84929268026