Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric alpha-Defensins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295542" target="_blank" >RIV/00216208:11130/15:10295542 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/15:00446217 RIV/00064203:_____/15:10295542

Výsledek na webu

<a href="http://dx.doi.org/10.1053/j.gastro.2015.05.009" target="_blank" >http://dx.doi.org/10.1053/j.gastro.2015.05.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1053/j.gastro.2015.05.009" target="_blank" >10.1053/j.gastro.2015.05.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric alpha-Defensins

Popis výsledku v původním jazyce

BACKGROUND & AIMS: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autoimmune disorder characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency, but patients also develop intestinal disorders. APECED is an autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE, which regulates immune tolerance) that allow self-reactive T cells to enter the periphery. Enteric a-defensins are antimicrobial peptides secretedby Paneth cells. Patients with APECED frequently have gastrointestinal symptoms and seroreactivity against secretory granules of Paneth cells. We investigated whether enteric a-defensins are autoantigens in humans and mice with AIRE deficiency. METHODS:We analyzed clinical data, along with serum and stool samples and available duodenal biopsies from 50 patients with APECED collected from multiple centers in Europe. Samples were assessed for expression of defensins and other molecules by

Název v anglickém jazyce

Gastrointestinal Autoimmunity Associated With Loss of Central Tolerance to Enteric alpha-Defensins

Popis výsledku anglicky

BACKGROUND & AIMS: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autoimmune disorder characterized by chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency, but patients also develop intestinal disorders. APECED is an autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE, which regulates immune tolerance) that allow self-reactive T cells to enter the periphery. Enteric a-defensins are antimicrobial peptides secretedby Paneth cells. Patients with APECED frequently have gastrointestinal symptoms and seroreactivity against secretory granules of Paneth cells. We investigated whether enteric a-defensins are autoantigens in humans and mice with AIRE deficiency. METHODS:We analyzed clinical data, along with serum and stool samples and available duodenal biopsies from 50 patients with APECED collected from multiple centers in Europe. Samples were assessed for expression of defensins and other molecules by

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

<a href="/cs/project/GBP302%2F12%2FG101" target="_blank" >GBP302/12/G101: Molekulární mechanismy signalizace receptory leukocytů - jejich role ve zdraví a nemocích.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gastroenterology

ISSN

0016-5085

e-ISSN

—

Svazek periodika

149

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

139-150

Kód UT WoS článku

000356610400030

EID výsledku v databázi Scopus

2-s2.0-84931412671