The Relationships Between Quantitative MR Parameters in Hippocampus in Healthy Subjects and Patients With Temporal Lobe Epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10295702" target="_blank" >RIV/00216208:11130/15:10295702 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/15:10295702 RIV/00023001:_____/15:00059092

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/64/64_407.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/64/64_407.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Relationships Between Quantitative MR Parameters in Hippocampus in Healthy Subjects and Patients With Temporal Lobe Epilepsy

Popis výsledku v původním jazyce

We introduce a new magnetic resonance (MR) method based on a pixel-by-pixel image processing to examine relationships between metabolic and structural processes in the pathologic hippocampus. The method was tested for lateralization of the epileptogeniczone in patients with temporal lobe epilepsy (TLE). Twenty patients with drug-resistant TLE and fifteen healthy controls were examined at 3T. The measurement protocol contained T2-weighted MR images, spectroscopic imaging, diffusion tensor imaging and T2relaxometry. Correlations between quantitative MR parameters were calculated on a pixel-by-pixel basis using the CORIMA program which enables automated pixel identification in the normal tissue according to control data. All MR parameters changed in theanteroposterior direction in the hippocampus and correlation patterns and their slopes differed between patients and controls. Combinations of T2 relaxation times with metabolite values represent the best biomarkers of the epileptogenic

Název v anglickém jazyce

The Relationships Between Quantitative MR Parameters in Hippocampus in Healthy Subjects and Patients With Temporal Lobe Epilepsy

Popis výsledku anglicky

We introduce a new magnetic resonance (MR) method based on a pixel-by-pixel image processing to examine relationships between metabolic and structural processes in the pathologic hippocampus. The method was tested for lateralization of the epileptogeniczone in patients with temporal lobe epilepsy (TLE). Twenty patients with drug-resistant TLE and fifteen healthy controls were examined at 3T. The measurement protocol contained T2-weighted MR images, spectroscopic imaging, diffusion tensor imaging and T2relaxometry. Correlations between quantitative MR parameters were calculated on a pixel-by-pixel basis using the CORIMA program which enables automated pixel identification in the normal tissue according to control data. All MR parameters changed in theanteroposterior direction in the hippocampus and correlation patterns and their slopes differed between patients and controls. Combinations of T2 relaxation times with metabolite values represent the best biomarkers of the epileptogenic

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS9915" target="_blank" >NS9915: Vlastnosti extracelulárního prostoru lidského epileptického neokortexu - význam v patogenezi a diagnostice farmakorezistentní epilepsie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

64

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

407-417

Kód UT WoS článku

000357411100013

EID výsledku v databázi Scopus

2-s2.0-84934276699