Structural alterations of the language connectome in children with specific language impairment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315261" target="_blank" >RIV/00216208:11130/15:10315261 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985807:_____/15:00451407 RIV/00064203:_____/15:10315261

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bandl.2015.10.003" target="_blank" >http://dx.doi.org/10.1016/j.bandl.2015.10.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bandl.2015.10.003" target="_blank" >10.1016/j.bandl.2015.10.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Structural alterations of the language connectome in children with specific language impairment

Popis výsledku v původním jazyce

We evaluated brain white matter pathways associated with language processing in 37 children with specific language impairment aged 6-12 years and 34 controls, matched for age, sex and handedness. Arcuate fascicle (AF), inferior fronto-occipital fascicle(IFOF), inferior longitudinal fascicle (ILF) and uncinate fascicle (UF) were identified using magnetic resonance diffusion tensor imaging (DTI). Diffusivity parameters and volume of the tracts were compared between the SLI and control group. Children with SLI showed decreased fractional anisotropy in all investigated tracts, increased mean diffusivity and radial diffusivity component in arcuate fascicle bilaterally, left IFOF and left ILF. Further, bilaterally increased volume of the ILF in children with SLI was found. We confirmed previous findings indicating deficient connectivity of the arcuate fascicle and as a novel finding, demonstrate abnormal development of the ventral language stream in patients with SLI.

Název v anglickém jazyce

Structural alterations of the language connectome in children with specific language impairment

Popis výsledku anglicky

We evaluated brain white matter pathways associated with language processing in 37 children with specific language impairment aged 6-12 years and 34 controls, matched for age, sex and handedness. Arcuate fascicle (AF), inferior fronto-occipital fascicle(IFOF), inferior longitudinal fascicle (ILF) and uncinate fascicle (UF) were identified using magnetic resonance diffusion tensor imaging (DTI). Diffusivity parameters and volume of the tracts were compared between the SLI and control group. Children with SLI showed decreased fractional anisotropy in all investigated tracts, increased mean diffusivity and radial diffusivity component in arcuate fascicle bilaterally, left IFOF and left ILF. Further, bilaterally increased volume of the ILF in children with SLI was found. We confirmed previous findings indicating deficient connectivity of the arcuate fascicle and as a novel finding, demonstrate abnormal development of the ventral language stream in patients with SLI.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/NT11443" target="_blank" >NT11443: Korelace MR traktografie, EEG analýz a počítačového zpracování řečového signálu u dětí s vývojovou dysfázií</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain and Language

ISSN

0093-934X

e-ISSN

—

Svazek periodika

151

Číslo periodika v rámci svazku

neuvedeno

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

35-41

Kód UT WoS článku

000367122300004

EID výsledku v databázi Scopus

2-s2.0-84947711345