Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315604" target="_blank" >RIV/00216208:11130/15:10315604 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/15:10315604

Výsledek na webu

<a href="http://dx.doi.org/10.3389/fimmu.2015.00588" target="_blank" >http://dx.doi.org/10.3389/fimmu.2015.00588</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2015.00588" target="_blank" >10.3389/fimmu.2015.00588</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Popis výsledku v původním jazyce

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall mmunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other mmunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishme

Název v anglickém jazyce

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

Popis výsledku anglicky

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall mmunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other mmunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishme

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Immunology [online]

ISSN

1664-3224

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

Listopad

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

24

Strana od-do

—

Kód UT WoS článku

000366120100002

EID výsledku v databázi Scopus

2-s2.0-84949681065