Efficacy of nasal irrigation with 2.2% hypertonic seawater in the treatment of chronic rhinosinusitis in adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F16%3A10427365" target="_blank" >RIV/00216208:11130/16:10427365 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/16:10427365

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kw79PUfMHW" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=kw79PUfMHW</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Efficacy of nasal irrigation with 2.2% hypertonic seawater in the treatment of chronic rhinosinusitis in adults

Popis výsledku v původním jazyce

Objective: To evaluate the efficacy and the tolerance of nasal irrigation with 2.2% hypertonic seawater in the treatment of chronic rhinosinusitis (CRS) in adults either used as monotherapy, or in combination with intranasal corticosteroids. Method: In this prospective, open-label, multicenter controlled trial, 238 patients diagnosed with CRS were randomly assigned to three groups: group 1 with intranasal corticosteroids (steroid), group 2 with nasal irrigation with hypertonic seawater (seawater) and group 3 with a treatment combining intranasal corticosteroids at lower dose and seawater (steroid+seawater). Nasal index score (NIS), patient health status, intranasal corticosteroids intake, tolerance were assessed at baseline, week 2 and 6, and satisfaction at week 6. Results: NIS was significantly improved in group 2 (seawater) and group 3 (steroid+seawater) at week 2 (p&lt; 0.001 in both groups) and week 6 (p&lt; 0.0001 in both groups) compared to group 1 (steroid), along with a significant decrease of intranasal corticosteroids (p &lt; 0.0001). Patient health status improved in group 2 and group 3 at week 2 (p= 0.1040 and p&lt; 0.001 respectively) compared to control (steroid), and this improvement was significantly greater in both groups at week 6 compared to steroid group (p&lt; 0.0001). Conclusion: Hypertonic nasal irrigation is an effective treatment for CRS in adults. It significantly improved nasal symptoms and allowed a significant decrease of intranasal corticosteroids use while improving patient health status. Nasal irrigation with 2.2% hypertonic seawater could therefore be considered as first-line treatment for CRS, either as monotherapy or in combination with lower dosage of intranasal corticosteroids.

Název v anglickém jazyce

Efficacy of nasal irrigation with 2.2% hypertonic seawater in the treatment of chronic rhinosinusitis in adults

Popis výsledku anglicky

Objective: To evaluate the efficacy and the tolerance of nasal irrigation with 2.2% hypertonic seawater in the treatment of chronic rhinosinusitis (CRS) in adults either used as monotherapy, or in combination with intranasal corticosteroids. Method: In this prospective, open-label, multicenter controlled trial, 238 patients diagnosed with CRS were randomly assigned to three groups: group 1 with intranasal corticosteroids (steroid), group 2 with nasal irrigation with hypertonic seawater (seawater) and group 3 with a treatment combining intranasal corticosteroids at lower dose and seawater (steroid+seawater). Nasal index score (NIS), patient health status, intranasal corticosteroids intake, tolerance were assessed at baseline, week 2 and 6, and satisfaction at week 6. Results: NIS was significantly improved in group 2 (seawater) and group 3 (steroid+seawater) at week 2 (p&lt; 0.001 in both groups) and week 6 (p&lt; 0.0001 in both groups) compared to group 1 (steroid), along with a significant decrease of intranasal corticosteroids (p &lt; 0.0001). Patient health status improved in group 2 and group 3 at week 2 (p= 0.1040 and p&lt; 0.001 respectively) compared to control (steroid), and this improvement was significantly greater in both groups at week 6 compared to steroid group (p&lt; 0.0001). Conclusion: Hypertonic nasal irrigation is an effective treatment for CRS in adults. It significantly improved nasal symptoms and allowed a significant decrease of intranasal corticosteroids use while improving patient health status. Nasal irrigation with 2.2% hypertonic seawater could therefore be considered as first-line treatment for CRS, either as monotherapy or in combination with lower dosage of intranasal corticosteroids.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30206 - Otorhinolaryngology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Revue de Laryngologie Otologie Rhinologie

ISSN

0035-1334

e-ISSN

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Svazek periodika

137

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

8

Strana od-do

3-10

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85023749524