Colorectal cancer in patients under the age of 40 years: experience from a tertiary care centre in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373179" target="_blank" >RIV/00216208:11130/17:10373179 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00099601 RIV/00064203:_____/17:10373179

Výsledek na webu

<a href="http://dx.doi.org/10.1080/00015458.2017.1321270" target="_blank" >http://dx.doi.org/10.1080/00015458.2017.1321270</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00015458.2017.1321270" target="_blank" >10.1080/00015458.2017.1321270</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Colorectal cancer in patients under the age of 40 years: experience from a tertiary care centre in the Czech Republic

Popis výsledku v původním jazyce

Introduction: Colorectal cancer (CRC) in young patients is not an uncommon disease. Reports on its behaviour in young patients are conflicting. The aim of this study was to investigate patient and tumour characteristics, treatment and prognosis of this disease. Methods: Our study group comprised all patients under the age of 40 years treated with CRC at the Department of Surgery at Motol University Hospital in Prague between the years 2005 and 2015. Results: Thirty-eight patients under 40 years of age diagnosed with CRC were included in the study. Five patients had Lynch syndrome and six had first-degree relatives with CRC. There were 22 rectal tumours. All but four patients underwent resection of the primary tumour, all patients received chemotherapy and 13 patients received biological therapy. Disease recurrence occurred in 25.8%. Five-year survival was 47.9%. Advanced disease and adverse histological subtypes were identified as poor prognostic factors. Conclusions: Colorectal cancer in young patients has a high incidence of predisposing conditions, aggressive histological features and advanced disease. Young patients are of a good state of health and thus should receive aggressive therapy. Clinicians should pay more attention to symptoms of CRC in young patients to be able to initiate early treatment.

Název v anglickém jazyce

Colorectal cancer in patients under the age of 40 years: experience from a tertiary care centre in the Czech Republic

Popis výsledku anglicky

Introduction: Colorectal cancer (CRC) in young patients is not an uncommon disease. Reports on its behaviour in young patients are conflicting. The aim of this study was to investigate patient and tumour characteristics, treatment and prognosis of this disease. Methods: Our study group comprised all patients under the age of 40 years treated with CRC at the Department of Surgery at Motol University Hospital in Prague between the years 2005 and 2015. Results: Thirty-eight patients under 40 years of age diagnosed with CRC were included in the study. Five patients had Lynch syndrome and six had first-degree relatives with CRC. There were 22 rectal tumours. All but four patients underwent resection of the primary tumour, all patients received chemotherapy and 13 patients received biological therapy. Disease recurrence occurred in 25.8%. Five-year survival was 47.9%. Advanced disease and adverse histological subtypes were identified as poor prognostic factors. Conclusions: Colorectal cancer in young patients has a high incidence of predisposing conditions, aggressive histological features and advanced disease. Young patients are of a good state of health and thus should receive aggressive therapy. Clinicians should pay more attention to symptoms of CRC in young patients to be able to initiate early treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Chirurgica Belgica

ISSN

0001-5458

e-ISSN

—

Svazek periodika

117

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

BE - Belgické království

Počet stran výsledku

7

Strana od-do

356-362

Kód UT WoS článku

000419273900002

EID výsledku v databázi Scopus

2-s2.0-85018256270