Sequential Burkholderia cenocepacia Isolates from Siblings with Cystic Fibrosis Show Increased Lung Cell Attachment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373194" target="_blank" >RIV/00216208:11130/17:10373194 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/17:10373194

Výsledek na webu

<a href="https://doi.org/10.1164/rccm.201607-1360LE" target="_blank" >https://doi.org/10.1164/rccm.201607-1360LE</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1164/rccm.201607-1360LE" target="_blank" >10.1164/rccm.201607-1360LE</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sequential Burkholderia cenocepacia Isolates from Siblings with Cystic Fibrosis Show Increased Lung Cell Attachment

Popis výsledku v původním jazyce

Burkholderia cepacia complex (Bcc) is a group of 20 genetically distinct bacterial species (1) that has a severe impact on the quality of life of people with cystic fibrosis (CF) and is associated with a more rapid decline of lung function than Pseudomonas aeruginosa (2). B. cenocepacia is the most virulent species within the Bcc and is most frequently associated with septicemia, although other Bcc species have also been linked to bloodstream infections (BSI) (2, 3). Many pathogens alter their phenotype during chronic infection in response to changing selection pressures, coinfecting species, and antimicrobial therapies (4, 5). Studies on bacterial adaptation in the CF context have predominantly focused on P. aeruginosa; however, the adaptive strategies of B. cenocepacia isolates have also been examined (4, 6, 7). Antimicrobial resistance, loss of motility, tolerance of iron limitation, and increased virulence to host cells over time of chronic infection were reported. In contrast, P. aeruginosa and another member of the Bcc, B. multivorans, showed reduced virulence over time of infection (5, 8). We have examined two series of sequential isolates from two adult male siblings with CF (referred to as P1 and P2). Both patients became infected with Bcc during their teens and were chronically infected when transitioning to adult care.

Název v anglickém jazyce

Sequential Burkholderia cenocepacia Isolates from Siblings with Cystic Fibrosis Show Increased Lung Cell Attachment

Popis výsledku anglicky

Burkholderia cepacia complex (Bcc) is a group of 20 genetically distinct bacterial species (1) that has a severe impact on the quality of life of people with cystic fibrosis (CF) and is associated with a more rapid decline of lung function than Pseudomonas aeruginosa (2). B. cenocepacia is the most virulent species within the Bcc and is most frequently associated with septicemia, although other Bcc species have also been linked to bloodstream infections (BSI) (2, 3). Many pathogens alter their phenotype during chronic infection in response to changing selection pressures, coinfecting species, and antimicrobial therapies (4, 5). Studies on bacterial adaptation in the CF context have predominantly focused on P. aeruginosa; however, the adaptive strategies of B. cenocepacia isolates have also been examined (4, 6, 7). Antimicrobial resistance, loss of motility, tolerance of iron limitation, and increased virulence to host cells over time of chronic infection were reported. In contrast, P. aeruginosa and another member of the Bcc, B. multivorans, showed reduced virulence over time of infection (5, 8). We have examined two series of sequential isolates from two adult male siblings with CF (referred to as P1 and P2). Both patients became infected with Bcc during their teens and were chronically infected when transitioning to adult care.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Respiratory and Critical Care Medicine

ISSN

1073-449X

e-ISSN

—

Svazek periodika

195

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

832-835

Kód UT WoS článku

000396640500020

EID výsledku v databázi Scopus

2-s2.0-85015957945