H-1-MRS metabolites and rate of beta-amyloid accumulation on serial PET in clinically normal adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373753" target="_blank" >RIV/00216208:11130/17:10373753 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1212/WNL.0000000000004421" target="_blank" >https://doi.org/10.1212/WNL.0000000000004421</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1212/WNL.0000000000004421" target="_blank" >10.1212/WNL.0000000000004421</a>

Jazyk výsledku

angličtina

Název v původním jazyce

H-1-MRS metabolites and rate of beta-amyloid accumulation on serial PET in clinically normal adults

Popis výsledku v původním jazyce

Objective: To assess whether noninvasive proton magnetic resonance spectroscopy (H-1-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of beta-amyloid (A beta) accumulation on serial PET in clinically normal (CN) older adults. Methods: Consecutive participants aged 60 years and older (n = 594) from the Mayo Clinic Study of Aging who were CN at baseline and who underwent H-1-MRS from the posterior cingulate voxel and longitudinal C-11-Pittsburgh compound B (PiB)-PET were included. The rate of A beta accumulation by serial cortical PiB standardized uptake value ratios was estimated as a function of baseline H-1-MRS metabolite ratios and time using mixed-effect models adjusted for age, sex, and APOE epsilon 4. Effect of APOE epsilon 4 on the relationship between baseline MRS and an increased rate of A beta accumulation was also assessed. Results: Among all participants, a higher myo-inositol (mI)/creatine (p = 0.011) and a lower Nacetylaspartate/mI (p = 0.006) at baseline were associated with an increased A beta accumulation over time after adjusting for age, sex, and APOE epsilon 4. APOE epsilon 4 did not modify the association of baseline H-1-MRS metabolite ratios and rate of A beta accumulation. However, APOE epsilon 4 carriers accumulated A beta faster than noncarriers regardless of the baseline A beta load (p = 0.001). Conclusion: Among CN older adults, early metabolic alterations on H-1-MRS and APOE epsilon 4 status are independently associated with an increased rate of A beta accumulation. Our findings could have important implications for early diagnosis and identification of individuals for secondary prevention trials, because an increased rate of A beta accumulation in CN older adults may confer a higher risk for cognitive decline and mild cognitive impairment.

Název v anglickém jazyce

H-1-MRS metabolites and rate of beta-amyloid accumulation on serial PET in clinically normal adults

Popis výsledku anglicky

Objective: To assess whether noninvasive proton magnetic resonance spectroscopy (H-1-MRS) tissue metabolite measurements at baseline can predict an increase in the rate of beta-amyloid (A beta) accumulation on serial PET in clinically normal (CN) older adults. Methods: Consecutive participants aged 60 years and older (n = 594) from the Mayo Clinic Study of Aging who were CN at baseline and who underwent H-1-MRS from the posterior cingulate voxel and longitudinal C-11-Pittsburgh compound B (PiB)-PET were included. The rate of A beta accumulation by serial cortical PiB standardized uptake value ratios was estimated as a function of baseline H-1-MRS metabolite ratios and time using mixed-effect models adjusted for age, sex, and APOE epsilon 4. Effect of APOE epsilon 4 on the relationship between baseline MRS and an increased rate of A beta accumulation was also assessed. Results: Among all participants, a higher myo-inositol (mI)/creatine (p = 0.011) and a lower Nacetylaspartate/mI (p = 0.006) at baseline were associated with an increased A beta accumulation over time after adjusting for age, sex, and APOE epsilon 4. APOE epsilon 4 did not modify the association of baseline H-1-MRS metabolite ratios and rate of A beta accumulation. However, APOE epsilon 4 carriers accumulated A beta faster than noncarriers regardless of the baseline A beta load (p = 0.001). Conclusion: Among CN older adults, early metabolic alterations on H-1-MRS and APOE epsilon 4 status are independently associated with an increased rate of A beta accumulation. Our findings could have important implications for early diagnosis and identification of individuals for secondary prevention trials, because an increased rate of A beta accumulation in CN older adults may confer a higher risk for cognitive decline and mild cognitive impairment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurology

ISSN

0028-3878

e-ISSN

—

Svazek periodika

89

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1391-1399

Kód UT WoS článku

000412594100020

EID výsledku v databázi Scopus

2-s2.0-85030610246