Ioduria and type 1 diabetes mellitus - Relationships to selected clinical markers of diabetes in adults

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373816" target="_blank" >RIV/00216208:11130/17:10373816 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/17:N0000025 RIV/00064203:_____/17:10373816

Výsledek na webu

<a href="https://doi.org/10.1016/j.jab.2016.11.002" target="_blank" >https://doi.org/10.1016/j.jab.2016.11.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2016.11.002" target="_blank" >10.1016/j.jab.2016.11.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ioduria and type 1 diabetes mellitus - Relationships to selected clinical markers of diabetes in adults

Popis výsledku v původním jazyce

There is a lack of data on the state of iodine reserves and the possible consequences of iodine deficits in diabetic patients. The main aims of this study were to: a) obtain information about iodine saturation in patients with type 1 diabetes; b) determine to what extent this saturation differs from the non-diabetic population; and c) determine whether iodine levels are related to several clinical and laboratory parameters characteristic of diabetic syndrome, including thyroid status. Subjects and methods: A total of 54 males and 51 females treated for type 1 diabetes mellitus (DM1) were included in this cross-sectional study. In addition to iodine saturation determined as the concentration of iodine in the first urine sample of the day, we measured clinical, anthropometric, and biochemical parameters in relation to DM1. Results: Measured iodine levels were: median 152 mu g/l, first quartile 117 mu g/l, and third quartile 219 mu g/l. More than 50% of iodine levels varied within the optimal saturation range of 100-200 mu g/l, while about 14% showed incomplete saturation (&lt; 100 mu g/l), and 34% had increased saturation (&gt; 200 mu g/l). Multi-dimensional regression showed significant positive relationships; (an OPLS model explaining 9% of the variability) between ioduria and male sex, body weight and height, and serum creatinine levels, which to date have not yet been published. Relationships to the other analyzed parameters (glycated hemoglobin, insulin dose, DM duration, body mass index, microalbuminuria, glomerular filtration rate, thyroid function and volume, thyroid autoimmune markers) were not significant. Conclusions: Iodine saturation levels in our study group were within the ICCIDD (WHO) recommendations for optimal/good saturation for the non-diabetic population, and patients with diabetic syndrome did not differ with respect to the chosen normal ioduria concentrations, i.e. 100 or 150 mu g/l. The question remains, however, whether past attempts to deal with iodine deficits in the Czech Republic are responsible for this satisfactory iodine status of the type 1 diabetic population, or if there are other factors involved.

Název v anglickém jazyce

Ioduria and type 1 diabetes mellitus - Relationships to selected clinical markers of diabetes in adults

Popis výsledku anglicky

There is a lack of data on the state of iodine reserves and the possible consequences of iodine deficits in diabetic patients. The main aims of this study were to: a) obtain information about iodine saturation in patients with type 1 diabetes; b) determine to what extent this saturation differs from the non-diabetic population; and c) determine whether iodine levels are related to several clinical and laboratory parameters characteristic of diabetic syndrome, including thyroid status. Subjects and methods: A total of 54 males and 51 females treated for type 1 diabetes mellitus (DM1) were included in this cross-sectional study. In addition to iodine saturation determined as the concentration of iodine in the first urine sample of the day, we measured clinical, anthropometric, and biochemical parameters in relation to DM1. Results: Measured iodine levels were: median 152 mu g/l, first quartile 117 mu g/l, and third quartile 219 mu g/l. More than 50% of iodine levels varied within the optimal saturation range of 100-200 mu g/l, while about 14% showed incomplete saturation (&lt; 100 mu g/l), and 34% had increased saturation (&gt; 200 mu g/l). Multi-dimensional regression showed significant positive relationships; (an OPLS model explaining 9% of the variability) between ioduria and male sex, body weight and height, and serum creatinine levels, which to date have not yet been published. Relationships to the other analyzed parameters (glycated hemoglobin, insulin dose, DM duration, body mass index, microalbuminuria, glomerular filtration rate, thyroid function and volume, thyroid autoimmune markers) were not significant. Conclusions: Iodine saturation levels in our study group were within the ICCIDD (WHO) recommendations for optimal/good saturation for the non-diabetic population, and patients with diabetic syndrome did not differ with respect to the chosen normal ioduria concentrations, i.e. 100 or 150 mu g/l. The question remains, however, whether past attempts to deal with iodine deficits in the Czech Republic are responsible for this satisfactory iodine status of the type 1 diabetic population, or if there are other factors involved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

146-150

Kód UT WoS článku

000402479300008

EID výsledku v databázi Scopus

2-s2.0-85007453609