Traditional Risk Factors of Acute Coronary Syndrome in Four Different Male Populations - Total Cholesterol Value Does Not Seem To Be Relevant Risk Factor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373902" target="_blank" >RIV/00216208:11130/17:10373902 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/17:10373902 RIV/00023001:_____/17:00060313

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_S121.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_S121.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Traditional Risk Factors of Acute Coronary Syndrome in Four Different Male Populations - Total Cholesterol Value Does Not Seem To Be Relevant Risk Factor

Popis výsledku v původním jazyce

Cardiovascular diseases are the most common cause of mortality and morbidity in most populations. As the traditional modifiable risk factors (smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity) were defined decades ago, we decided to analyze recent data in patients who survived acute coronary syndrome (ACS). The Czech part of the study included data from 999 males, and compared them with the post-MONICA study (1,259 males, representing general population). The Lithuanian study included 479 male patients and 456 age-matched controls. The Kazakhstan part included 232 patients and 413 controls. In two countries, the most robust ACS risk factor was smoking (OR 3.85 in the Czech study and 5.76 in the Lithuanian study), followed by diabetes (OR 2.26 and 2.07) and hypertension (moderate risk elevation with OR 1.43 and 1.49). These factors did not influence the ACS risk in Kazakhstan. BMI had no significant effect on ACS and plasma cholesterol was surprisingly significantly lower (P&lt;0.001) in patients than in controls in all countries (4.80 +/- 1.11 vs. 5.76 +/- 1.06 mmol/l in Czechs; 5.32 +/- 1.32 vs. 5.71 +/- 1.08 mmol/l in Lithuanians; 4.88 +/- 1.05 vs. 5.38 +/- 1.13 mmol/l in Kazakhs/Russians). Results from our study indicate substantial heterogeneity regarding major CVD risk factors in different populations with the exception of plasma total cholesterol which was inversely associated with ACS risk in all involved groups. These data reflect ethnical and geographical differences as well as changing pattern of cardiovascular risk profiles.

Název v anglickém jazyce

Traditional Risk Factors of Acute Coronary Syndrome in Four Different Male Populations - Total Cholesterol Value Does Not Seem To Be Relevant Risk Factor

Popis výsledku anglicky

Cardiovascular diseases are the most common cause of mortality and morbidity in most populations. As the traditional modifiable risk factors (smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity) were defined decades ago, we decided to analyze recent data in patients who survived acute coronary syndrome (ACS). The Czech part of the study included data from 999 males, and compared them with the post-MONICA study (1,259 males, representing general population). The Lithuanian study included 479 male patients and 456 age-matched controls. The Kazakhstan part included 232 patients and 413 controls. In two countries, the most robust ACS risk factor was smoking (OR 3.85 in the Czech study and 5.76 in the Lithuanian study), followed by diabetes (OR 2.26 and 2.07) and hypertension (moderate risk elevation with OR 1.43 and 1.49). These factors did not influence the ACS risk in Kazakhstan. BMI had no significant effect on ACS and plasma cholesterol was surprisingly significantly lower (P&lt;0.001) in patients than in controls in all countries (4.80 +/- 1.11 vs. 5.76 +/- 1.06 mmol/l in Czechs; 5.32 +/- 1.32 vs. 5.71 +/- 1.08 mmol/l in Lithuanians; 4.88 +/- 1.05 vs. 5.38 +/- 1.13 mmol/l in Kazakhs/Russians). Results from our study indicate substantial heterogeneity regarding major CVD risk factors in different populations with the exception of plasma total cholesterol which was inversely associated with ACS risk in all involved groups. These data reflect ethnical and geographical differences as well as changing pattern of cardiovascular risk profiles.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

66

Číslo periodika v rámci svazku

Supplement 1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

"S121"-"S128"

Kód UT WoS článku

000398620900014

EID výsledku v databázi Scopus

2-s2.0-85017129263