Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10367235" target="_blank" >RIV/00216208:11130/18:10367235 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/18:00493722 RIV/00216208:11140/18:10367235 RIV/61989592:15110/18:73590309 RIV/00209805:_____/18:00077992 RIV/61988987:17110/18:A20020QD

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-018-02942-5" target="_blank" >10.1038/s41467-018-02942-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Popis výsledku v původním jazyce

In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9,040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P=4.35x10-8). Replication of ten promising signals in up to 2,737 patients and 4,752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P=8.36x10-14), rs2941471 at 8q21.11 (HNF4G, P=6.60x10-10), rs4795218 at 17q12 (HNF1B, P=1.32x10-8), and rs1517037 at 18q21.32 (GRP, P=3.28x10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic datasets, provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.

Název v anglickém jazyce

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Popis výsledku anglicky

In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9,040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P=4.35x10-8). Replication of ten promising signals in up to 2,737 patients and 4,752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P=8.36x10-14), rs2941471 at 8q21.11 (HNF4G, P=6.60x10-10), rs4795218 at 17q12 (HNF1B, P=1.32x10-8), and rs1517037 at 18q21.32 (GRP, P=3.28x10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic datasets, provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Communications [online]

ISSN

2041-1723

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000424451300001

EID výsledku v databázi Scopus

2-s2.0-85041960929