An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10377419" target="_blank" >RIV/00216208:11130/18:10377419 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/18:10377419

Výsledek na webu

<a href="https://doi.org/10.4149/neo_2018_171107N716" target="_blank" >https://doi.org/10.4149/neo_2018_171107N716</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2018_171107N716" target="_blank" >10.4149/neo_2018_171107N716</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study

Popis výsledku v původním jazyce

The BCOR-CCNB3 positive sarcoma is a recently identified sarcoma morphologically and clinically similar to Ewing sarcoma in adolescents and young adults. The BCOR-CCNB3 fusion transcript originates from a paracentric inversion on the X chromosome with an in-frame fusion between the last codon of BCOR and the exon 5 of CCNB3 gene. We report morphological and molecular genetic analysis of 8 undifferentiated sarcomas positive for the BCOR-CCNB3 fusion. Six of the eight BCOR-CCNB3 positive sarcoma patients were male. Five of the eight patients were in their second decade of life (median of all patients 14 years at diagnosis). The bone marrow involvement was demonstrated in 2 of 4 patients tested. Detection of the fusion transcripts BCOR-CCNB3 in the bone marrow suggests that patients with positive findings are at high risk of the tumor progression.

Název v anglickém jazyce

An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study

Popis výsledku anglicky

The BCOR-CCNB3 positive sarcoma is a recently identified sarcoma morphologically and clinically similar to Ewing sarcoma in adolescents and young adults. The BCOR-CCNB3 fusion transcript originates from a paracentric inversion on the X chromosome with an in-frame fusion between the last codon of BCOR and the exon 5 of CCNB3 gene. We report morphological and molecular genetic analysis of 8 undifferentiated sarcomas positive for the BCOR-CCNB3 fusion. Six of the eight BCOR-CCNB3 positive sarcoma patients were male. Five of the eight patients were in their second decade of life (median of all patients 14 years at diagnosis). The bone marrow involvement was demonstrated in 2 of 4 patients tested. Detection of the fusion transcripts BCOR-CCNB3 in the bone marrow suggests that patients with positive findings are at high risk of the tumor progression.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

—

Svazek periodika

65

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

630-636

Kód UT WoS článku

000440172400018

EID výsledku v databázi Scopus

2-s2.0-85051273571