Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10380363" target="_blank" >RIV/00216208:11130/18:10380363 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15110/18:73589223
Výsledek na webu
<a href="https://doi.org/10.1038/s41467-018-05890-2" target="_blank" >https://doi.org/10.1038/s41467-018-05890-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-018-05890-2" target="_blank" >10.1038/s41467-018-05890-2</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
Popis výsledku v původním jazyce
Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.
Název v anglickém jazyce
Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
Popis výsledku anglicky
Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30502 - Other medical science
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Nature Communications [online]
ISSN
2041-1723
e-ISSN
—
Svazek periodika
9
Číslo periodika v rámci svazku
September
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
12
Strana od-do
—
Kód UT WoS článku
000445562800006
EID výsledku v databázi Scopus
2-s2.0-85053845843