Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10383559" target="_blank" >RIV/00216208:11130/18:10383559 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/18:00498725 RIV/67985807:_____/18:00498725 RIV/68407700:21230/18:00324487

Výsledek na webu

<a href="https://doi.org/10.1038/s41593-018-0278-y" target="_blank" >https://doi.org/10.1038/s41593-018-0278-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41593-018-0278-y" target="_blank" >10.1038/s41593-018-0278-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Popis výsledku v původním jazyce

The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.

Název v anglickém jazyce

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Popis výsledku anglicky

The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Neuroscience

ISSN

1097-6256

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

1742-1752

Kód UT WoS článku

000451324700012

EID výsledku v databázi Scopus

2-s2.0-85057290648