The BDNF Val66Met polymorphism modulates resilience of neurological functioning to brain ageing and dementia: A narrative review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10410908" target="_blank" >RIV/00216208:11130/20:10410908 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/20:00072906 RIV/00064203:_____/20:10410908

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b8hmUnwhIW" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=b8hmUnwhIW</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/brainsci10040195" target="_blank" >10.3390/brainsci10040195</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The BDNF Val66Met polymorphism modulates resilience of neurological functioning to brain ageing and dementia: A narrative review

Popis výsledku v původním jazyce

Brain-derived neurotropic factor (BDNF) is an abundant and multi-function neurotrophin in the brain. It is released following neuronal activity and is believed to be particularly important in strengthening neural networks. A common variation in the BDNF gene, a valine to methionine substitution at codon 66 (Val66Met), has been linked to differential expression of BDNF associated with experience-dependent plasticity. The Met allele has been associated with reduced production of BDNF following neuronal stimulation, which suggests a potential role of this variation with respect to how the nervous system may respond to challenges, such as brain ageing and related neurodegenerative conditions (e.g., dementia and Alzheimer&apos;s disease). The current review examines the potential of the BDNF Val66Met variation to modulate an individual&apos;s susceptibility and trajectory through cognitive changes associated with ageing and dementia. On balance, research to date indicates that the BDNF Met allele at this codon is potentially associated with a detrimental influence on the level of cognitive functioning in older adults and may also impart increased risk of progression to dementia. Furthermore, recent studies also show that this genetic variation may modulate an individual&apos;s response to interventions targeted at building cognitive resilience to conditions that cause dementia. (C) 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Název v anglickém jazyce

The BDNF Val66Met polymorphism modulates resilience of neurological functioning to brain ageing and dementia: A narrative review

Popis výsledku anglicky

Brain-derived neurotropic factor (BDNF) is an abundant and multi-function neurotrophin in the brain. It is released following neuronal activity and is believed to be particularly important in strengthening neural networks. A common variation in the BDNF gene, a valine to methionine substitution at codon 66 (Val66Met), has been linked to differential expression of BDNF associated with experience-dependent plasticity. The Met allele has been associated with reduced production of BDNF following neuronal stimulation, which suggests a potential role of this variation with respect to how the nervous system may respond to challenges, such as brain ageing and related neurodegenerative conditions (e.g., dementia and Alzheimer&apos;s disease). The current review examines the potential of the BDNF Val66Met variation to modulate an individual&apos;s susceptibility and trajectory through cognitive changes associated with ageing and dementia. On balance, research to date indicates that the BDNF Met allele at this codon is potentially associated with a detrimental influence on the level of cognitive functioning in older adults and may also impart increased risk of progression to dementia. Furthermore, recent studies also show that this genetic variation may modulate an individual&apos;s response to interventions targeted at building cognitive resilience to conditions that cause dementia. (C) 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Sciences [online]

ISSN

2076-3425

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

195

Kód UT WoS článku

000534271500043

EID výsledku v databázi Scopus

2-s2.0-85082853957