Exhausted phenotype of follicular CD8 T cells in CVID

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10410932" target="_blank" >RIV/00216208:11130/20:10410932 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/20:10410932

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8Bsd1OQXwp" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8Bsd1OQXwp</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jaci.2020.02.025" target="_blank" >10.1016/j.jaci.2020.02.025</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exhausted phenotype of follicular CD8 T cells in CVID

Popis výsledku v původním jazyce

A unique subset of CD8 T cells has been recently observed in germinal centers (GCs), a location traditionally associated with CD4 T-B interaction and humoral immune response. These follicular CD8 (fCD8) T cells appear to play a role in controlling chronic viral infections such as lymphocytic choriomeningitis virus, hepatitis B, or HIV and are expanded in malignant lymphoproliferation, but their role may be more diverse, as illustrated by their involvement in promoting antibody class switch in mice with autoimmune disease. Susceptibility to viral and bacterial infections, lymphoproliferation, cancer, and autoimmunity are complications seen in most patients with common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency with the hallmark of impaired GC-derived specific antibody responses. Our group has previously described an increased prevalence of CD8+ cells in the GCs of patients with CVID and lymphadenopathy. Given the recent emergence of fCD8 T cells as important players in lymphoproliferation and regulation of the GC reaction, we investigated these cells in greater detail using methods described in this article&apos;s Online Repository at www.jacionline.org.

Název v anglickém jazyce

Exhausted phenotype of follicular CD8 T cells in CVID

Popis výsledku anglicky

A unique subset of CD8 T cells has been recently observed in germinal centers (GCs), a location traditionally associated with CD4 T-B interaction and humoral immune response. These follicular CD8 (fCD8) T cells appear to play a role in controlling chronic viral infections such as lymphocytic choriomeningitis virus, hepatitis B, or HIV and are expanded in malignant lymphoproliferation, but their role may be more diverse, as illustrated by their involvement in promoting antibody class switch in mice with autoimmune disease. Susceptibility to viral and bacterial infections, lymphoproliferation, cancer, and autoimmunity are complications seen in most patients with common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency with the hallmark of impaired GC-derived specific antibody responses. Our group has previously described an increased prevalence of CD8+ cells in the GCs of patients with CVID and lymphadenopathy. Given the recent emergence of fCD8 T cells as important players in lymphoproliferation and regulation of the GC reaction, we investigated these cells in greater detail using methods described in this article&apos;s Online Repository at www.jacionline.org.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/NV18-05-00162" target="_blank" >NV18-05-00162: Moderní přístupy k primárním imunodeficiencím: uplatnění molekulární a funkční diagnostiky v terapii</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Allergy and Clinical Immunology

ISSN

0091-6749

e-ISSN

—

Svazek periodika

146

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

912-915

Kód UT WoS článku

000582395800022

EID výsledku v databázi Scopus

2-s2.0-85082675573