Seroprevalence of Borrelia IgM and IgG Antibodies in Healthy Individuals: A Caution Against Serology Misinterpretations and Unnecessary Antibiotic Treatments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10411072" target="_blank" >RIV/00216208:11130/20:10411072 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/20:10411072

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ArZZDs1X1s" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ArZZDs1X1s</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/vbz.2020.2632" target="_blank" >10.1089/vbz.2020.2632</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Seroprevalence of Borrelia IgM and IgG Antibodies in Healthy Individuals: A Caution Against Serology Misinterpretations and Unnecessary Antibiotic Treatments

Popis výsledku v původním jazyce

In Lyme disease, the interpretation of diagnostic assays is often misunderstood. Cross-reactions of Borrelia proteins with antigens from other bacterial species are well known. Therefore, to diagnose Lyme disease, the finding of positive IgM antibodies must be accompanied by objectively verified clinical signs and a history of a possible tick exposure. Positive Borrelia IgM antibodies in healthy individuals with nonspecific clinical symptoms are likely a false-positive result for Lyme disease and neither long-term antibiotic treatment nor cycling of different antibiotic regimens is beneficial. To date, there is clear evidence that positive serology does not indicate infection with Borrelia species. Borrelia serology has been reported to be positive for months or years in similar to 20% of healthy patients who had experienced Lyme disease in the past. Thus, serology as a single diagnostic tool has a very limited value and should be used only to support clinically suspected cases.

Název v anglickém jazyce

Seroprevalence of Borrelia IgM and IgG Antibodies in Healthy Individuals: A Caution Against Serology Misinterpretations and Unnecessary Antibiotic Treatments

Popis výsledku anglicky

In Lyme disease, the interpretation of diagnostic assays is often misunderstood. Cross-reactions of Borrelia proteins with antigens from other bacterial species are well known. Therefore, to diagnose Lyme disease, the finding of positive IgM antibodies must be accompanied by objectively verified clinical signs and a history of a possible tick exposure. Positive Borrelia IgM antibodies in healthy individuals with nonspecific clinical symptoms are likely a false-positive result for Lyme disease and neither long-term antibiotic treatment nor cycling of different antibiotic regimens is beneficial. To date, there is clear evidence that positive serology does not indicate infection with Borrelia species. Borrelia serology has been reported to be positive for months or years in similar to 20% of healthy patients who had experienced Lyme disease in the past. Thus, serology as a single diagnostic tool has a very limited value and should be used only to support clinically suspected cases.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Vector-Borne and Zoonotic Diseases

ISSN

1530-3667

e-ISSN

—

Svazek periodika

20

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

800-802

Kód UT WoS článku

000532241200001

EID výsledku v databázi Scopus

2-s2.0-85092680719