'Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea' - Author's reply

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10411849" target="_blank" >RIV/00216208:11130/20:10411849 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064211:_____/20:W0000024

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1_fZ_Bk459" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1_fZ_Bk459</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cmi.2020.02.033" target="_blank" >10.1016/j.cmi.2020.02.033</a>

Jazyk výsledku

angličtina

Název v původním jazyce

'Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea' - Author's reply

Popis výsledku v původním jazyce

We are grateful to Dr Sfeir for the insightful comments on our paper. We completely agree that a major limitation with Neisseria gonorrhoeae nucleic acid amplification tests (NAATs) is the lack of complete antimicrobial resistance (AMR) data, which only gonococcal culture can offer. However, in studies focusing on examination of rectal and pharyngeal specimens (as in our study), a gonococcal NAAT for diagnosis is essential due to the exceedingly low sensitivity using culture:: i.e., ideally both NAAT and culture should be used for all specimens, but this is not always cost-effective or feasible. This strongly emphasizes the importance of developing appropriate rapid molecular assays to predict gonococcal AMR, which ideally could detect N. gonorrhoeae and multiple AMR determinants, and could be used at the point of care. Such assays could be used for diagnosis of gonorrhoea, to inform individualized treatment (sparing the last line of empirical treatment), and for AMR surveillance.

Název v anglickém jazyce

'Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea' - Author's reply

Popis výsledku anglicky

We are grateful to Dr Sfeir for the insightful comments on our paper. We completely agree that a major limitation with Neisseria gonorrhoeae nucleic acid amplification tests (NAATs) is the lack of complete antimicrobial resistance (AMR) data, which only gonococcal culture can offer. However, in studies focusing on examination of rectal and pharyngeal specimens (as in our study), a gonococcal NAAT for diagnosis is essential due to the exceedingly low sensitivity using culture:: i.e., ideally both NAAT and culture should be used for all specimens, but this is not always cost-effective or feasible. This strongly emphasizes the importance of developing appropriate rapid molecular assays to predict gonococcal AMR, which ideally could detect N. gonorrhoeae and multiple AMR determinants, and could be used at the point of care. Such assays could be used for diagnosis of gonorrhoea, to inform individualized treatment (sparing the last line of empirical treatment), and for AMR surveillance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Microbiology and Infection

ISSN

1198-743X

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

2

Strana od-do

799-800

Kód UT WoS článku

000536144300033

EID výsledku v databázi Scopus

2-s2.0-85085006605