Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et al

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412360" target="_blank" >RIV/00216208:11130/20:10412360 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/20:10412360

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JVNy_iJkB8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JVNy_iJkB8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcf.2019.10.009" target="_blank" >10.1016/j.jcf.2019.10.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et al

Popis výsledku v původním jazyce

Background: Cystic fibrosis related diabetes (CFRD) has implications for morbidity and mortality with several risk factors identified. We studied the epidemiology of CFRD in the large dataset of the European Cystic Fibrosis Society Patient registry. Methods: Data on CF patients were investigated for the prevalence of CFRD as well as for any association with suggested risk factors and effects. Results: CFRD increased by approximately ten percentage points every decade from ten years of age. Prevalence was higher in females in the younger age groups. CFRD was associated with severe CF genotypes (OR = 3.11, 95%CI: 2.77-3.48), pancreatic insufficiency (OR = 1.46, 95%CI: 1.39-1.53) and female gender (OR = 1.28, 95%CI: 1.21-1.34). Patients with CFRD had higher odds of being chronically infected with Pseudomonas aeruginosa, Burkholderia cepacia complex and Stenotrophomonas maltophilia than patients without CFRD, higher odds of having FEV1% of predicted &lt;40% (OR = 1.82, 95%CI: 1.70-1.94) and higher odds of having BMI SDS &lt;=-2 than patients without CFRD (OR = 1.24, 95%CI: 1.15-1.34). Conclusions: Severe genotype, pancreatic insufficiency and female gender remain considerable intrinsic risk factors for early acquisition of CFRD. CFRD is associated with infections, lower lung function and poor nutritional status. Early diagnosis and aggressive treatment of CFRD are more important than ever with increasing life span. (C) 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Cystic fibrosis related diabetes in Europe: Prevalence, risk factors and outcome; Olesen et al

Popis výsledku anglicky

Background: Cystic fibrosis related diabetes (CFRD) has implications for morbidity and mortality with several risk factors identified. We studied the epidemiology of CFRD in the large dataset of the European Cystic Fibrosis Society Patient registry. Methods: Data on CF patients were investigated for the prevalence of CFRD as well as for any association with suggested risk factors and effects. Results: CFRD increased by approximately ten percentage points every decade from ten years of age. Prevalence was higher in females in the younger age groups. CFRD was associated with severe CF genotypes (OR = 3.11, 95%CI: 2.77-3.48), pancreatic insufficiency (OR = 1.46, 95%CI: 1.39-1.53) and female gender (OR = 1.28, 95%CI: 1.21-1.34). Patients with CFRD had higher odds of being chronically infected with Pseudomonas aeruginosa, Burkholderia cepacia complex and Stenotrophomonas maltophilia than patients without CFRD, higher odds of having FEV1% of predicted &lt;40% (OR = 1.82, 95%CI: 1.70-1.94) and higher odds of having BMI SDS &lt;=-2 than patients without CFRD (OR = 1.24, 95%CI: 1.15-1.34). Conclusions: Severe genotype, pancreatic insufficiency and female gender remain considerable intrinsic risk factors for early acquisition of CFRD. CFRD is associated with infections, lower lung function and poor nutritional status. Early diagnosis and aggressive treatment of CFRD are more important than ever with increasing life span. (C) 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cystic Fibrosis

ISSN

1569-1993

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

321-327

Kód UT WoS článku

000542305900027

EID výsledku v databázi Scopus

2-s2.0-85074475996